| 陈兆斌,蔡加平,姜汉明,王忠泽.江苏省东台市一起流行性脑脊髓膜炎暴发的流行病学调查[J].Chinese journal of Epidemiology,2005,26(11):900 |
| 江苏省东台市一起流行性脑脊髓膜炎暴发的流行病学调查 |
| Study on the association between inflammatory factor and insulin resistance as well as type 2 diabetes with macrovascular complications |
| Received:March 28, 2005 |
| DOI： |
| KeyWord: 糖尿病,2型 C反应蛋白 大血管病变 胰岛素抵抗 |
| English Key Word: Diabetes, type 2 Ultrasensitive C-reactive protein Mactrovascular complications Insulin resistance |
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| Abstract: |
| 江苏省东台市唐洋镇中学2005年1月18～26日发生6 例疑似流行性脑脊髓膜炎(流脑)的暴发, 经细菌和血清学检查确认为C群脑膜炎球菌引起;现将调查结果报道如下. 1. 对象与方法:资料来自所有流脑病例流行病学个案调查及唐洋镇中学基本情况调查. 病例均采集脑脊液和急性期、恢复期双份血清标本, 送江苏省疾病预防控制中心进行细菌学和血清学检测. |
| English Abstract: |
| Objective To study the possible associatin between C-reactive(CRP) and insulin resistance(IR) as well as the pathogenesis of type 2 diabetes macrovascular complication. Methods Serum CRP was measured by ultrasensitive immuoturbidimetiric, which was determined on type 2 diabetes(T2DM) with or without macrovascular complication(70 and 60 cases respectively) and on normal controls(90 cases). IR was estimated by homeostasis model assessment(HOMA-IR). Results Results showed that the concentration of CRP was higher in T2DM with or without macrovascular complications than that in the healthy subjects (P＜0.01), while it was higher in diabetic patients with macrovascular complications than that in diabetic patients without macrovascular complications (P＜0.01). In diabetic patients with macrovascular complications, person correlation analysis indicated that there existed positive correlations between CRP and FINS,HOMA-IR, triglyceride(TG) while stepwise linear regression showed that usCRP and HOMA-IR, TG having linear correlation. Conclusion CRP seemed to play a role in the initiation and progression of atherosclerosis in type 2 diabetes, possibly was by the way of IR. |
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