中国慢性阻塞性肺疾病患病率调查方法的研究设计

周玉民; 刘升明; 吕嘉春; 郑劲平; 钟南山; 冉丕鑫

Abstract

周玉民,刘升明,吕嘉春,郑劲平,钟南山,冉丕鑫.中国慢性阻塞性肺疾病患病率调查方法的研究设计[J].Chinese journal of Epidemiology,2006,27(9):814-818

中国慢性阻塞性肺疾病患病率调查方法的研究设计

A study on the methodology regarding the prevalence survey of chronic obstructive pulmonary disease in China

Received:January 19, 2006

DOI：

KeyWord: 肺疾病,慢性阻塞性流行病学方法学

English Key Word: Pulmonary disease,chronic obstructive Epidemiology Methodology

FundProject:国家“十五”攻关资助项目[2001BA703B03(A)];广东省“十五”重点支持项目(B30301)

Author Name	Affiliation	E-mail
ZHOU Yu-min	Guarzgzhou Institute of Respiratory Disease,First Affiliated Hospital of Guangzhou Medical College,Guangzhou 510120,China
LIU Sheng-ming	Guarzgzhou Institute of Respiratory Disease,First Affiliated Hospital of Guangzhou Medical College,Guangzhou 510120,China
LV Jia-chun	Guarzgzhou Institute of Respiratory Disease,First Affiliated Hospital of Guangzhou Medical College,Guangzhou 510120,China
ZHENG Jin-ping	Guarzgzhou Institute of Respiratory Disease,First Affiliated Hospital of Guangzhou Medical College,Guangzhou 510120,China
ZHONG Nan-shan	暨南大学第一附属医院呼吸科
RAN Pi-xin	暨南大学第一附属医院呼吸科	pxran@gzhmc.edu.cn

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Abstract:

目的探讨与国际接轨的慢性阻塞性肺疾病(COPD)患病率调查方法,以获取中国准确的COPD流行病学资料。方法为全国7个省/市的COPD横断面调查。在中国7个地区(北京、上海、广东、辽宁、天津、重庆和陕西),采用多阶段分层(城乡)整群随机抽样方法,分别抽取一个农村和一个城市调查点,最小的整群抽样单位为村和居委会,其中所有户籍登记40岁及以上居民均进行问卷调查和肺功能检测,问卷调查表参照COPD疾病负担研究(BOLD)制定而成,主要包括COPD可能相关的危险因素、临床症状、生存质量评估、诊断及防治状况等。对肺功能FEV1/FVC<70%者,进行支气管扩张试验、体格检查、X线胸片和心电图检测。以支气管扩张试验后FEV1/FVC<70%作为诊断COPD的标准。结果所有调查点都按统一标准和要求完成了流行病学调查,调查结果符合质量控制的要求,各协作中心的肺功能合格率都在85．0%以上,问卷合格率都在95．0%以上。总体资料合格(包括问卷和肺功能都合格)率为95.2%,总体有效应答率为79.0%。结论该方案是与国际接轨的COPD流行病调查方法,具有科学性和可行性。

English Abstract:

Objective To explore the methodology on prevalence study of chronic obstructive pulmonary disease (COPD) in line with the world, to obtain accurate epidemic data of COPD in China.Methods A national multi-center cross-sectional survey on prevalence, risk factors and burden of COPD was conducted in China. In each area, a population-based cluster sample of approximately 1450 individuals aged 40 years or older was interviewed, using standardized questionnaires that were revised on them ethodology of burden of lung diseases (BOLD) study and according under the context of China. All participants were submitted to pre-bronchodilator spirometry. Those with airflow limitation received post-bronchodilator spirometry, physical examination, X-rays of chest and EKG (electrocardiogram) tests. The post-bronchodialators FEVl/FVC<70% was identified as having COPD. Results Investigation has been completed with the same standardized procedures by all sites, up to the requirement of quality control. Over85.0 % of the spirometry tests and 95，0 % of questionnaires had met the criteria of quality control in each area. Overall, 95.2%of the data was valid with acceptable spirometry and question aire, and the valid response rate was 79. 0.Conclusion The protocol was in line with the international standards,by whichthe prevalence of COPD in China was of adequate quality and valid.

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