| 杨建民,路方红,金世宽,孙尚文,赵颖馨,王舒健,周晓红.山东省40岁以上人群心脑血管病死亡事件影响因素的队列研究[J].Chinese journal of Epidemiology,2007,28(2):119-122 |
| 山东省40岁以上人群心脑血管病死亡事件影响因素的队列研究 |
| A cohort study on the predictive value of factors influencing cardio-eerebro vascular death among people over 40 years of age |
| Received:June 30, 2006 |
| DOI： |
| KeyWord: 血压 心脑血管病 死亡事件 危险因素 |
| English Key Word: Blood pressure Cardif>eerebro vascular disease Death incident Risk factor |
| FundProject: |
| Author Name | Affiliation | E-mail | | Yang Jian-min | Department of Cardiology, Cnrdio Cerebro Vascular Control and Research Center, Shandong Academy of Medical Sciences,Jinan 250062, China | | | Lu Fang-hong | Department of Cardiology, Cnrdio Cerebro Vascular Control and Research Center, Shandong Academy of Medical Sciences,Jinan 250062, China | lufanghongming@tom.cotrt | | Jin Shi-kuan | Department of Cardiology, Cnrdio Cerebro Vascular Control and Research Center, Shandong Academy of Medical Sciences,Jinan 250062, China | | | Sun Shang-wen | Department of Cardiology, Cnrdio Cerebro Vascular Control and Research Center, Shandong Academy of Medical Sciences,Jinan 250062, China | | | Zhao Ying-xin | Department of Cardiology, Cnrdio Cerebro Vascular Control and Research Center, Shandong Academy of Medical Sciences,Jinan 250062, China | | | Wang Shu-jian | Department of Cardiology, Cnrdio Cerebro Vascular Control and Research Center, Shandong Academy of Medical Sciences,Jinan 250062, China | | | Zhou Xiao-hong | Department of Cardiology, Cnrdio Cerebro Vascular Control and Research Center, Shandong Academy of Medical Sciences,Jinan 250062, China | |
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| Abstract: |
| 目的: 探讨各因素对心脑血管病死亡的影响和作用强度及各因素在不同年龄段作用的差异。方法: 对11008名人群进行基线调查, 随访8年, 应用Cox回归分析各因素对心脑血管病死亡的预测价值。结果: 心脑血管病死亡事件的发生与脑卒中史、吸烟、收缩压(SBP)、舒张压(DBP)、年龄有关。40～59岁人群主要危险因素相对危险度分为: 脑卒中史(4.903)、DBP每增加10 mm Hg(1.366,1 mm Hg=0.133 kPa)、吸烟(1+157)、年龄每增加1岁(1+098); 60～74岁人群分别为: 脑卒中史(2.405)、吸烟(1.231)、SBP每增加10 toni Hg(1.201)、体重指数每增加1(1.141)、年龄每增加l岁(1.095); ≥75岁人群:仅年龄每增加1岁(1.068)有统计学意义。结论: 各因素对心脑血管病死亡的预测价值在不同年龄段是不同的, 不同年龄段的人群应侧重于不同的危险因素的预防与控制。 |
| English Abstract: |
| Objeetive: To explore the factors influencing eardio-eerebro vascular death events among people over 40 years of age in Shandong area.China. Methods: Baseline survey was carried out in 1991. A total number of 11008 adults over 40 years old had been studied in Shandong province. Data on cardio-cerebro death was collected. The correlation between influencing factors and cardio-cerebro vascular death events was analyzed by Cox regression model. Results: Totally, 434 cardio～cerebro death events occurred among the 11008 subjects during the 8-year follow-up study. Cardio-cerebro death events were related to systolic blood pressure, diastolic blood pressure, smoking, stroke history and age. Data from Cox regression analysis showed that the relative risk(RR)for cardio cerebro vascular death events increased by 2.862 [95%confidence interval(CI):1.976-4.144] times for those people having stroke history. When systolic blood pressure, diastolic blood pressure increased by every 10 mm Hg,the relative risk for cardic-cerebro vascular death events increased by 1.17l (95%CI:1.033-1.328), 1.214 (95% CI:1.044-1.413) respectively. It was found that a 1.239 (95% C1:1.088-1.553) times higher in smokers than non-smokers on relative risk for cardio-cerebro vascular death events. However, the predictive values of the influencing factors for cardio.cerebro vascular death were different among population of different years of age. The relative risk for cardio-cerebro vascular death events increased by 1.366 (95% CI:1.102 1.678) times for each 10 him Hg increase of diastolic blood pressure in 40-59 years old population. However, the effect was taken place by systolic blood pressure in 60-74 years old population. with a relative risk of 1.201 (95% CI:1.017-1.418) for each 10 mm Hg increase. Age seemed the only significant factor for cardio-cerehro vascular dearh events on population aged more than 75 years old. Conclusion: The predictive values of the risk factors were different among age groups. The different risk factors should be taken care according to the difference of age. |
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