215例抑郁症患者自杀未遂危险因素的配对病例对照研究

张玉琦; 袁国桢; 李桂林; 姚建军; 程灶火; 储兴; 刘朝军; 刘庆海; 王爱荣; 史桂芝; 王宝恒; 成义仁; 张明廉; 李克

Abstract

张玉琦,袁国桢,李桂林,姚建军,程灶火,储兴,刘朝军,刘庆海,王爱荣,史桂芝,王宝恒,成义仁,张明廉,李克.215例抑郁症患者自杀未遂危险因素的配对病例对照研究[J].Chinese journal of Epidemiology,2007,28(2):131-135

215例抑郁症患者自杀未遂危险因素的配对病例对照研究

A case-control study on the risk factors for attempted suicide in patients with major depression

Received:April 20, 2006

DOI：

KeyWord: 抑郁症自杀未遂色氨酸羟化酶基因单核苷酸多态性病例对照研究

English Key Word: Major depression Suicidal attempt TPH2 gene Single nucleotide polymorphism Case-control study

FundProject:江苏省“333工程”基金资助项目

Author Name	Affiliation
Zhang Yu-qi	Wuxi Mental Health Center, Nanjing Medical College, Wuxi 214151, China
Yuan Guo-zhen	Wuxi Mental Health Center, Nanjing Medical College, Wuxi 214151, China
Li Guilin	Wuxi Mental Health Center, Nanjing Medical College, Wuxi 214151, China
Yao Jian-jun	Wuxi Mental Health Center, Nanjing Medical College, Wuxi 214151, China
Cheng Zao-huo	Wuxi Mental Health Center, Nanjing Medical College, Wuxi 214151, China
Chu Xing	Wuxi Mental Health Center, Nanjing Medical College, Wuxi 214151, China
Liu Chao-jun	山东省安康医院精神科, 济宁 272100
Liu Qing-hai	山东省安康医院精神科, 济宁 272100
Wang Ai-rong	山东省安康医院精神科, 济宁 272100
Shi Gui-zhi	汕头大学医学院分子遗传学教研室, 汕头 515063
Wang Bao-heng	汕头大学医学院分子遗传学教研室, 汕头 515063
Cheng Yi-ren	山东省安康医院精神科, 济宁 272100
Zhang Ming-lian	Wuxi Mental Health Center, Nanjing Medical College, Wuxi 214151, China
Li Ke	汕头大学医学院分子遗传学教研室, 汕头 515063

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Abstract:

目的: 了解汉族人群抑郁症患者自杀未遂的环境危险因素、色氨酸羟化酶2(TPH2)基因rs7305115单核苷酸多态性与自杀未遂有无关联。方法: 采用配对病例对照研究, 对215例自杀未遂者(男性92例、女性123例)与相应对照(与病例同性别、年龄相差3岁以内、同地区)进行TPH2 rs7305115基因型测定、自杀行为干预研究量表调查环境因素与抑郁症自杀未遂的关系研究。结果: 研究组与对照组在TPI-L2 rs7305115基因型、基因频率的差异有统计学意义(P<0.001); 多因素条件 logistic回归模型分析显示, 绝望、负性生活事件、有自杀家族史, 均为抑郁症自杀未遂危险因素, OR值分别为7.68(95%CI:5.79～13.74)、6.64(95%Cj:2.48～11,04)、2.98(95%CI:1.17～5.04); TPH2 rs7305115 A/A为抑郁症自杀未遂的保护因素0.33(95%CI:0.22～0.99)。结论: 绝望、负性生活事件、自杀家族史是抑郁症自杀未遂的危险因素, TPH2 rs7305115 A/A可能是抑郁症自杀行为的保护因素。

English Abstract:

0bjective: To understand the environmental risk factors on attempted suicide in patients with major depression, and to study the interaction between factors as single nucleotide polymorphism (SNP) of TPH2 gene rs7305115 associated to attempted suicide in major depression. Methods: Paired case-control study on 215 suicide attempters with major depression(92 male, 123 female) and molecular biological techniques were used to study the relation between TPH2 gene rs7305115 SNP.interrelated environmental factors and the rate of attempted suicide. Controls were paired with cases according to the same gender similar age (no more than 3 years) and from the same district. Results: There were remarkably significant differences in gene types and gene frequency between case and control groups (P<0.001). Data from multivariate conditional logistic regression model analysis showed that hopelessness,negative life-events and family history of suicide were relationship of attempted suicide in patients with major depression with OR values as 0.33 ( 95% CI:0.22.0.99), 7.68 ( 95% CI:5.79-13.74), 6.64( 95% CI:2.48 11.04), 2.98 ( 95% CI: 1.17-5.04) respectively. There was no first level interaetion between any of the two risk factors. Conclusion: Results from the study supported the idea that hopelessness. negative life-events and fanfily history of suicide were risk factors of attempted suicide in major depression while TPH2 geners7305115 A/A might be the protective factor.

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