居室内毒素含量与儿童过敏性哮喘相关性调查

胡东; 张荣波; 吴静

Abstract

胡东,张荣波,吴静.居室内毒素含量与儿童过敏性哮喘相关性调查[J].Chinese journal of Epidemiology,2007,28(4):354-357

居室内毒素含量与儿童过敏性哮喘相关性调查

Study on the relations between concentration of endotoxin in dwelling and atopic asthma in school-age children

Received:September 05, 2006

DOI：

KeyWord: 哮喘内毒素暴露

English Key Word: Asthma Endotoxin Exposure

FundProject:

Author Name	Affiliation
HU Dong	School of Medicine, Anhui University of Science and Technology, Huainan 232001, China
ZHANG Rongbo	School of Medicine, Anhui University of Science and Technology, Huainan 232001, China
WU Jing	School of Medicine, Anhui University of Science and Technology, Huainan 232001, China

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Abstract:

目的<\b> 了解居室内毒素含量对儿童过敏性哮喘患病率的影响.方法<\b> 向安徽省安庆、淮南地区2986名8或12岁在校儿童父母发放哮喘标准调查表,动态浊度法检测儿童床铺尘内毒素含量,放射性变应原荧光酶免疫吸附实验(RAST-FEIA)检测其血清中特异性IgE(sIgE)含量.结果<\b> 最终具有完整资料儿童为904人,居室内毒素含量与儿童过敏性哮喘患病率呈负相关(OR=0.48,95% CI:0.32～0.72,P＜0.05),与过敏性致敏呈负相关(OR=0.65,95% CI:0.49～0.94,P＜0.05),与非过敏性哮喘及哮鸣无显著相关.与正常人群相比,过敏性致敏、哮鸣、哮喘者的内毒素水平显著升高(M-W U 15 138.0,P＜0.01;M-W U 4858.0,P＜0.01;M-W U 4041.0,P＜0.01).结论<\b> 居室内毒素的早期暴露可能是预防儿童过敏性哮喘及致敏产生的保护因素之一

English Abstract:

Objective<\b> To explore the effect of endotoxin concentration in dwellings on the prevalence of atopic asthma in children.Methods<\b> Standardized questionnaires of asthma were distributed to the parents of 2986 sch∞l children aged between 8 and 12 years and endotoxin content in children’s mattress was measured by a kinetic limulus assay.A radioallergosorbent technique-fluorescence enzyme immunoassav(RAST-FEIA)was used to measure the level of specific IgE in serum.Results<\b> Complete data was available for 904 children with males more than females.There were both negative associations seen between endotoxin levels and both atopic asthma(OR=0.48，95％CI：0.32，0.72，P<0.05)and atopic sensitization(oR=O.65，95％Cf：0.49-0.94，P<0.05)but not with non-atopic asthma and wheeze.(bmparing with normaI people，patients with atopic sensitization，atopic wheeze and atopic asthma had a higher levels of endotoxin(M-W U：15 138.0，P<0.01，M-W U：4858.0，P<0.01，M.W U： 4041.0，PConclusion<\b> Exposure to endotoxin in early lives of children might have a protective effecton atopic asthma and sensitization.

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