| 周芳,傅君芬,王春林,梁黎,赵正言.儿童期肥胖与睡眠时间及胰岛素抵抗的关系[J].Chinese journal of Epidemiology,2007,28(9):910-913 |
| 儿童期肥胖与睡眠时间及胰岛素抵抗的关系 |
| Study on the relationships of childhood obesity and the duration of sleep as well as insulin resistance |
| Received:February 12, 2007 Revised:September 10, 2007 |
| DOI： |
| KeyWord: 肥胖 儿童期 睡眠时间 胰岛素抵抗 |
| English Key Word: Childhood obesity Duration of sleep Insulin resistance |
| FundProject:浙江省科技厅资助项目(2004C30064) |
| Author Name | Affiliation | E-mail | | ZHOU Fang | Department of Endocrinology, Children's Hospital of School of Medicine, Zhejiang University, Hangzhou 310003, China | | | FU Jun-fen | Department of Endocrinology, Children's Hospital of School of Medicine, Zhejiang University, Hangzhou 310003, China | fjf68@yahoo.com.cn | | WANG Chun-lin | Department of Endocrinology, Children's Hospital of School of Medicine, Zhejiang University, Hangzhou 310003, China | | | LIANG Li | Department of Endocrinology, Children's Hospital of School of Medicine, Zhejiang University, Hangzhou 310003, China | | | ZHAO Zheng-yan | Department of Endocrinology, Children's Hospital of School of Medicine, Zhejiang University, Hangzhou 310003, China | |
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| Abstract: |
| 目的探讨儿童期肥胖与睡眠时间及胰岛素抵抗的关系。方法269名体重指数(BMI)≥23 kg/m~2的7～15岁单纯性肥胖儿童按BMI不同分为三组:A组(23≤BMI25)57名,B组(25≤BMI30)164,C组(BMI≥30)72名。对肥胖儿童及120名正常健康儿童分别记录睡眠时间。所有肥胖儿童均行口服葡萄糖耐量试验和胰岛素释放试验;对照组中70名儿童测定空腹血糖(FBG)及空腹胰岛素(FINS),均分别计算稳态模型胰岛素抵抗指数(HOMA-IR),稳态模型胰岛口细胞功能(HOMA-IS)。结果3组肥胖儿童的睡眠时间均短于对照组,FBG、FINS和HOMA-IR均高于对照组(均P0.05),肥胖B组和C组HOMA-IS均高于对照组(均P0.05),而3组肥胖儿童之间、A组与对照组之间差异均无统计学意义(均P0.05)。对儿童期肥胖影响因素做多因素logistic回归分析显示,睡眠时间对肥胖有影响(P0.05),对胰岛素抵抗影响因素做多重线性回归分析显示BMI值对HOMA-IR和HOMA-IS均有影响(P0.05),且BMI增加一个单位,HOMA-IR和HOMA-IS则分别随之增加0.261个单位和11.054个单位。结论睡眠时间减少者更易发生肥胖;BMI与胰岛素抵抗存在明显的相关性,随着BMI的增加发生胰岛素抵抗的风险亦随之增加。 |
| English Abstract: |
| Objective To investigate the relationships of childhood obesity and the duration of sleep as well as insulin resistance.Methods Two hundred and sixty-nine simple obese children aged from 7 to 15 years with body mass index(BMI)over 23 and 120 normal healthy children were recruited in this study. Obese children were divided into three groups:Group A:23≤BMI25;Group B:25≤BMI30;Group C:BMI≥30.Duration of sleep was calculated according to the reported sleeping hours during working days and weekends.Oral glucose tolerance test and insulin releasing test were performed in all obese children. Seventy of the 120 healthy children received fasting plasma glucose(FBG)and fasting insulin(FINS) detection.Homeostasis model assessment-insulin resistance(HOMA-IR)and isletβcell secreting index (HOMA-IS)were calculated.Results The duration of sleep was shorter in all 3 obese groups than that in the control group and the levels of FBG,FINS and HOMA-IR were higher(P0.05).The levels of HOMA-IS in Group B and C were higher than that in the control group(P0.05),while HOMA-IS did not show much difference among the 3 obese groups and between Group A and the control group(P0.05).Logistic analysis showed that the duration of sleep was related to childhood obese(P0.05). Results from multiple linear regression model analysis showed that BMI bore a relation to HOMA-IR and HOMA-IS(P0.05),as well as one unit increase in BMI accompanied with 0.261 and 11.054 increase in HOMA-IR and HOMA-IS,respectively.Conclusion Children with shorter duration of sleep were susceptible to become obese.A significant correlation did exist between BMI and insulin resistance. |
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