| 张林峰,武阳丰,李莹,李贤,谢高强,赵连成.中国人群中父母脑卒中史与脑卒中发病关系的前瞻性研究[J].Chinese journal of Epidemiology,2007,28(11):1060-1063 |
| 中国人群中父母脑卒中史与脑卒中发病关系的前瞻性研究 |
| A cohort study on parentaI history and risk factors of stroke in Chinese population |
| Received:August 30, 2007 |
| DOI： |
| KeyWord: 脑卒中 危险因素 流行病学 |
| English Key Word: Stroke Risk factors Epidemiology |
| FundProject: |
| Author Name | Affiliation | | ZHANG Lin-feng | Department of Epidemiology, Fu Wai Cardiovascular Hospital, Peking Union Medical College and Chinese Academy Science, Beijing 100037, China | | WU Yang-feng | 北京大学公共卫生学院 | | LI Ying | Department of Epidemiology, Fu Wai Cardiovascular Hospital, Peking Union Medical College and Chinese Academy Science, Beijing 100037, China | | LI Xian | Department of Epidemiology, Fu Wai Cardiovascular Hospital, Peking Union Medical College and Chinese Academy Science, Beijing 100037, China | | XIE Gao-qiang | Department of Epidemiology, Fu Wai Cardiovascular Hospital, Peking Union Medical College and Chinese Academy Science, Beijing 100037, China | | ZHAO Lian-cheng | Department of Epidemiology, Fu Wai Cardiovascular Hospital, Peking Union Medical College and Chinese Academy Science, Beijing 100037, China |
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| Abstract: |
| 目的探讨中国人群中父母脑卒中史与子代脑卒中发病的关系。方法1992-1994年在全国12组人群中，分别整群随机抽取1000～2000人进行心血管病危险因素调查，并对心血管事件的发生情况进行随访观察，随访至2005年6月，平均随访10.8年。结果15 131例随访对象共发生脑卒中事件370例。在控制了年龄、性别后，父母双方均无脑卒中史者、仅父母一方有脑卒中史者、父母双方均有脑卒中史者发生脑卒中的相对危险分别为1.00、1.74(1.33～2.29)和3.61(1.86～7.01)。在进一步控制了基线时的吸烟、饮酒、总胆固醇、高密度脂蛋白胆固醇、空腹血糖、体重指数和收缩压后，上述各组发生脑卒中的相对危险分别为1.00、1.34(1.02～1.77)和2.50(1。29～4.87)。结论父母有脑卒中史者具有较高的发生脑卒中危险性，父母双方均有脑卒中者脑卒中发病危险的增加尤为显著。 |
| English Abstract: |
| objective To asseSs the relationship between parental history and the incidence of strokein Chinese populations.methods A total of 15 131 individuals(7015 men and 8116 women，aged from35 to 59 years)in China were enrolled and followed up from 1 992 to 2005. Information on the parentalhistory of stroke of the participants was collected at baseline study under face to face interview. Individualswere divided into three groups according t。their parental history of hypertension：those with no parentalhistory。f hypertension(Group 1)，those with。nly。ne parent having the histor)，of hypertensi。n(Group2)and those with both parents having the history of hypertensi。n(Group 3). The hazard ratio and its95％confidence interval were calculated using the Cox proportional hazard model. results There were370 stroke events during 163 858 person-years of observation.After adjusting for age and sex，the hazardratio on stroke for gIDup 1，group 2 and group 3 were 1.00，1.74(1.33-2.29)，3.61(1.86-7.01)，respectively.After acUusting for age，sex，sm。king，drinking，serum total cholesterol(TC)，high densitylipid cholesterol(HDL-C)，fasting glucose，body mass index(BMI)and systolic bl∞d pressure(SBP)inthemodel，the hazard ratio for stroke of those three groups were 1.00，1.34(1.02-1.77)，2.50(1.29-4.87)，respectively.conclusion Individuals with parental history of stroke had a higher risk of stroke，and this was especially true for t}10se with both parents having the history of stroke. |
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