应用BED-CEIA方法估算重庆市静脉吸毒人群艾滋病病毒感染的发病率

韩梅; 王豫林; 王慜杰; 周全华; 蒋岩

Abstract

韩梅,王豫林,王慜杰,周全华,蒋岩.应用BED-CEIA方法估算重庆市静脉吸毒人群艾滋病病毒感染的发病率[J].Chinese journal of Epidemiology,2007,28(11):1077-1080

应用BED-CEIA方法估算重庆市静脉吸毒人群艾滋病病毒感染的发病率

Application of BED-CEIA to estimate the human immunodeficiency Virus preVaIence among injecting drugllsers in Chongqing municipality

Received:April 12, 2007

DOI：

KeyWord: 艾滋病病毒 BED一酶联方法发病率静脉吸毒人群

English Key Word: Human immunodeficiency virus BED-capture enzyme immunoassay Incidence Iniection drug users

FundProject:中美艾滋病防治合作资金资助项目(5u62PS022883-5)

Author Name	Affiliation	E-mail
HAN Mei	Chongqing Center for Disease Cortlrol and Prevention, Chongqing 400042, China
WANG Yu-lin	Chongqing Center for Disease Cortlrol and Prevention, Chongqing 400042, China
WANG Min-jie	中国疾病预防控制中心性病艾滋病预防控制中心
ZHOU Quan-hua	Chongqing Center for Disease Cortlrol and Prevention, Chongqing 400042, China
JIANG Yan	中国疾病预防控制中心性病艾滋病预防控制中心	jiangyan03@263.Net

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Abstract:

目的检测重庆市静脉吸毒人群中艾滋病病毒(HIV)新近感染状况并计算HIv发病率。方法收集重庆市两个监测哨点自1999-2006年以来的监测样本共计4711份，通过酶联免疫和蛋白印迹实验检测出HIV一1感染的样本，再应用Ig-G一捕获HIV一1 BED一发病率酶联方法(BED-CEIA)，检测其中的新近感染样本，进而估算该人群的HIv.1发病率。结果共检出HIv一1阳性样品130份。哨点A 2001-2005年HIV感染率分别为O.73％、2.02％、1.54％、2.96％、2.80％，发病率分别为O.57％、0.93％、0、1.24％、1.68％；哨点B 2004 2006年HIV感染率分别为4.21％、9.96％、8.13％，发病率分别为O.95％、1.04％、O.90％。虽然两个哨点在发病率方面都有起伏，但差异无统计学意义，感染率与发病率变化趋势一致。结论目前在莺庆市监测哨点发现的HIV感染者大部分为既往感染者，发病率维持在较稳定的范围。

English Abstract:

objective To estimate the human immunodeficiency virus(HIV一1) prevalence ofinjecting drug users(IDUs)in Chongqing city. methods To apply BED-capture enzyme immunoassay(CEIA) which was based on the principle of HIV-antibody va ries as the disease progress， in order toestimate both the HIV incidence and prevaIence of IDUs from two IDUs surveillance sites in C}10ngqing.results Du“ng the research period，4711 serum samples were tested bv ELISA and 130 were HIV一1positive，confirmed by Western blot.The prevalence of IDUs surveillance site A from 1 999 to 2006 were0.73％，2.02％，1.54％，2.96％and 2.80％，and the incidence rates were O.57％，O.93％，0，1.24％and 1.68％ respectivelv. The prevalence of IDUs surveillance site B appeared to be 4.21％，9.96％，8.13％，and the incidence rates were 0.95％，1.04％and 0.90％respectively，from 2004 to 2006.conclusion Many of the IDUs HIV carriers in Chongqing had been infected for long time， and theincidence rates among them were steady，keeping at the same level for 1-2 years. PrOmotion on interventionfor IDUs had produced certain effects but more attention still necds to be paid.

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