| 张福杰,豆智慧,于兰,马烨,汪宁,曹广华,李传涛,赵金先,孟向东,乔晓
春,霍伟,赵红心,刘中夫,王烈,尚红.中国既往不安全有偿供血感染HIV者自然史双向性队列研究[J].Chinese journal of Epidemiology,2008,29(1):9-12 |
| 中国既往不安全有偿供血感染HIV者自然史双向性队列研究 |
| An ambispective cohort study of the natural history of HIV infection among former unsafe commercial blood and plasma donors |
| Received:August 17, 2007 Revised:June 12, 2012 |
| DOI： |
| KeyWord: HIV感染 中位潜伏期 中位生存期 双向性队列研究 |
| English Key Word: HIV infection Median incubation period Median survival time Ambispective cobort study |
| FundProject:北京市科委基金资助项目(H030930030430,H030930030031);首都发展基金资助项目(2002-2005) |
| Author Name | Affiliation | | ZHANG Fu-jie | 云南省玉溪市红塔区疾病预防控制中心,653100 | | DOU Zhi-hui | 云南省玉溪市红塔区疾病预防控制中心,653100 | | YU Lan | 云南省玉溪市红塔区疾病预防控制中心,653100 | | MA Ye | 云南省玉溪市红塔区疾病预防控制中心,653100 | | WANG Ning | 云南省玉溪市红塔区疾病预防控制中心,653100 | | CAO Guang-hua | 云南省玉溪市红塔区疾病预防控制中心,653100 | | LI Chuan-tao | 中国疾病预防控制中心传染病预防控制所 | | ZHAO Jin-xian | 玉溪市红塔区北城卫生院 | | MENG Xiang-dong | 玉溪市红塔区春和卫生院 | | QIAO Xiao-chun | 玉溪市红塔区高仓卫生院 | | HUO Wei |
National Center for AIDS|STD Control and Prevention, Chinese Center for Disease and Prevention, Beijing 10050, China
| | ZHAO Hong-xin |
National Center for AIDS|STD Control and Prevention, Chinese Center for Disease and Prevention, Beijing 10050, China
| | LIU Zhong-fu |
National Center for AIDS|STD Control and Prevention, Chinese Center for Disease and Prevention, Beijing 10050, China
| | WANG Lie |
National Center for AIDS|STD Control and Prevention, Chinese Center for Disease and Prevention, Beijing 10050, China
| | SHANG Hong |
National Center for AIDS|STD Control and Prevention, Chinese Center for Disease and Prevention, Beijing 10050, China
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| Abstract: |
| 目的 探讨中国既往不安全有偿供血员HIV感染自然史及其影响因素.方法 采用双向性队列研究方法，从国家艾滋病综合防治示范区中抽取6个省的10个县(区)，选择所有2006年7月24日前发现并确认既往不安全有偿采血(浆)者HIV/AIDS病例，收集其感染、发病、死亡信息及影响因素.采用SPSS 12.0统计软件分析.结果 (1)在7551例HIV感染者中，典型进展者6533例(86.52%，其中AIDS患者4757例)，快速进展者108例(1.43%)，长期不进展者910例(12.05%).(2)目前已经进展为AIDS者4865例(64.43%)，AIDS中位潜伏期为9年(95%CI:8.96～9.04)|至今累计未应用抗病毒药物治疗者1157例(占AIDS 23.78%)，其中死亡283例，这些未治疗的AIDS死亡者中位生存时间为6个月(95%C/:4～7)，2、3年病死率分别为95%、99%.(3)AIDS潜伏期长短与性别、感染HIV时年龄无关(P＞0.05)|未治疗的AIDS患者生存时间长短与性别有关(P＜0.05)，但与诊断AIDS时年龄、文化程度、婚姻无关(P＞0.05).结论 研究结果与UNAIDS提出的成年人慢速疾病进展规律比较，所得潜伏期略长而AIDS自然生存期较短，但与其他途径感染HIV人群潜伏期相近。 |
| English Abstract: |
| Objective Discussing the natural history and the influencing factors of HIV infection among former commerical blood and plasma donors engaged in unsafe blood donation pracitees in China. Methods Using ambispective aobort study, with data obtained from ten countries (districts) from six provinces in the National AIDS Control Demonstration Area. HIV/AIDS cases were found and confirmed prior to July 24, 2006 being former commerical blood. Plasma donors were selected and data regarding infection, incidence, death, and influencing factors was collected. Analysis was performed using SPSS 12.0 statistical anslysis software. Results (1)In 7551 cases of HIV infection, there were 6533 typical progressors(12.05%) with 4865 cases of AIDS, 108 rapid progressors(1.43%), 910long-term momprogressors |
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