中国人脂联素基因45T/G与276G/T多态性与2型糖尿病相关性研究的Meta分析

徐明彤; 陈筱潮; 金莉子; 陈维清

Abstract

徐明彤,陈筱潮,金莉子,陈维清.中国人脂联素基因45T/G与276G/T多态性与2型糖尿病相关性研究的Meta分析[J].Chinese journal of Epidemiology,2008,29(11):1132-1136

中国人脂联素基因45T/G与276G/T多态性与2型糖尿病相关性研究的Meta分析

A Meta-analysis on the association between adiponectin gene 45T/G/276G/T polymorphisms and type 2 diabetes in Chinese population

Received:April 06, 2008

DOI：

KeyWord: 2型糖尿病脂联素基因多态性中国人 Meta分析

English Key Word: Type 2 diabetes Adiponectin Gene polymorphism Chinese Meta-analysis

FundProject:广东省科技发展计划基金资助项目(200583370321);珠海市科技局基金资助项目(PB20051015)

Author Name	Affiliation
XU Ming-tong	Department of Orthopedics, The Second Affiliated Hospital of Guangzhou Traditional Chinese Medicine University, Guangzhou 510120, China
CHEN Xiao-chao	中山大学附属第五医院心内科
JIN Li-zi	中山大学附属第五医院心内科
CHEN Wei-qing	中山大学公共卫生学院流行病学教研窒

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Abstract:

目的对中国人脂联素基因45T/G和276G/T多态性与2型糖尿病相关性的研究进行Meta分析.方法通过文献检索收集2007年12月以前完成或发表的中国人脂联素基因45T/G和276G/T多态性与2型糖尿病相关性的病例对照研究,剔除不符合要求的文献,以漏斗图检验人选文献的偏倚,并根据各入选文献结果的同质性检验结果进行数据合并,计算总OR值,Meta分析采用Review Manager 4.2版软件.结果共23篇文献符合条件纳入研究,其中涉及45T/G多态性文献20篇,涉及276G/T多态性文献9篇,入选文献无明显偏倚,各文献间质性检验显示有关两个位点45T/G(X²=119.8,P<0.001)、276G/T(X²=31.0,P=0.001)等位基因分布情况的文献之间均存在显著异质性.Meta分析显示45G等位基因携带者增加2型糖尿病的易感性(OR=1.38,95%CI:1.04～1.84,P=0.03),276G/T基因多态性与2型糖尿病易感性无明显相关性(OR=0.83,95%CI:0.61～1.13,P=0.23).结论脂联素基因45T/G多态性与中国人2型糖尿病易感性相关,45G等位基因可能是2型糖尿病易感基因,276G/T基因多态性与2型糖尿病无明显相关性.

English Abstract:

Objective Association between the 45T/G and 276G/T single nueleotide polymorphisms of adiponectin gene and the occurrence of type 2 diabetes in Chinese population was studied. Methods 20 studies consisting 22 ease-control comparisons about 45T/G polymorphism and nine case-control studies about 276G/T polymorphism that were based on our inclusion criterion and available in the literature were reviewed. Results Results from Meta-analysis demonstrated a large heterogeneity among the studies both on 45T/G and 276G/T polymorphisms and a significant association was observed between 45T/G polymorphism at exon 2 of the adiponectin gene and type 2 diabetes among the Chinese population. 45Gallele appeared to be one of the genetic risk factors for susceptibility to type 2 diabetes with a random effects odds ratio ( OR ) of 1.43 ( 95 % CI : 1.17-1.75 ), and the G allele carriers were more susceptible to the disease with an OR of 1.38 ( 95 % CI : 1.04-1.84 ). Results from Meta-analysis, however, showed no association between the 276G/T polymorphism and type 2 diabetes in the Chinese populationr while the random effects OR of the allele 276T to susceptibility of disease was 0.83 (95% CI: 0.61-1.13).Conclusion The current paper on Meta-analysis demonstrated a correlation between the 45T/G single nucleotide polymorphism and the occurrence of type 2 diabetes in Chinese population, which was different from the findings that such an association with 276G/T polymorphism could not be demonstrated in the same ethnic population.

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