| 吴晓冰,代丽萍,王彦平,王凯娟,张建营.DNA切除修复基因XPD751位点多态性与食管癌发病风险的Meta分析[J].Chinese journal of Epidemiology,2009,30(3):281-285 |
| DNA切除修复基因XPD751位点多态性与食管癌发病风险的Meta分析 |
| DNA repair gene xeroderma pigmentosum group D 751 polymorphism and the risk on esophageal cancer:a Meta-analysis |
| Received:November 25, 2008 |
| DOI：10.3760/cma.j.issn.0254-6450.2009.03.020 |
| KeyWord: 食管癌 着色性干皮病基因D 基因多态性 Meta分析 |
| English Key Word: Esophageal cancer Xeroderma pigmentosum group D Gene polymorphism Meta-analysis |
| FundProject:围家自然科学基金资助项目(30872181) |
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| Abstract: |
| 目的 探讨DNA切除修复基因XPD751位点多态性与食管癌的发病风险关系. 方法 检索中外数据库, 获得有关XPD751位点多态性与食管癌发病风险的病例对照研究资料进行Meta分析, 并按组织学类型进行分层分析, 得到合并OR值(95%CI). 结果 共纳入文献11篇, 研究12项, 累计食管癌病例2558例, 对照5122例, 与野生基因型Lys/Lys相比, Lys/Gln、Gln/Gln和(Lys/Gln+Gln/Gln)合并的OR值(95%CI)分别为1. 19(1. 05, 1. 34)、1. 22(0. 86, 1. 74)、1. 20(1. 01, 1. 42). 分层分析显示, 累计食管鳞癌病例1417例, 对照2312例, 携带Lys/Gln、(Lys/Gln+Gln/Gln)的个体患食管鳞癌的风险分别是Lys/Lys的1. 22倍(95%CI:1. 02, 1. 46)、1. 24倍(95%C1:1. 01, 1. 47);累计食管腺癌病例935例, 对照2604例, 未发现XPD751位点多态性与食管腺癌发病风险的统计学相关性. 结论 XPD751位点杂合基因型Lys/Gln和(Lys/Gln+Gln/Gln)是食管癌发病的危险因素. XPD751位点杂合基因型Lys/Gln和(Lys/Gln+Gin/Gin)与食管鳞痛的发病风险相关, 未发现XPD751位点多态性与食管腺癌的发病风险有关. |
| English Abstract: |
| Objective To explore the association between XPD codon 751 polymorphism and esophageal cancer(EC)by systematically reviewing the risk of the original studies. Methods A comprehensive search was conducted to identify all case-control studies of XPD codon 751 polymorphism and EC risk. Meta-analysis was applied with Rev Man 4. 2 software for calculation of pooled OR value(with 95%C1)of EC, esophageal squamous cell carcinoma(ESCC)and esophageal adenocarcinoma(EAC). Results Of the 12 case-control studies selected for this Meta-analysis, a total of 2558 EC cases and 5122 controls were included. Compared with the wild-type homozygote Lys/Lys, the pooled Odds Ratios(with 95% CI)of Lys/Gln, Gin/Gin, (Lys/Gln + Gln/Gln)genotypes of XPD codon 751 polymorphism for EC risk were 1. 19(1. 05, 1. 34), 1. 22(0. 86, 1. 74), 1. 20(1. 01, 1. 42), respectively. In a stratified analysis, a total of 1417 ESCC cases and 2312 controls were included, and individuals carrying Lys/Gln genotype or(Lys/Gln+Gln/Gln)had 1. 22-fold or 1. 24-fold excess risks for ESCC compared with those carrying Lys/Lys genotype. A total of 935 EAC cases and 2604 controls were included, and none of the genotype of XPD codon 751 genetic polymorphism was found to be related to EAC. Conclusion Both heterogyzote Lys/Gln and(Lys/Gln + Gln/Gln)for XPD codon 751 genetic polymorphism were associated with an increased risk of developing esophageal cancer. Furthermore, heterogyzote Lys/Gln and(Lys/Gln + Gln/Gln)for XPD codon 751 genetic polymorphism might have increased the risk of ESCC, but have no association with EAC. |
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