| 张饭,王海俊,马军.儿童青少年肥胖与神经肽Y第二受体基因多态性[J].Chinese journal of Epidemiology,2009,30(7):695-698 |
| 儿童青少年肥胖与神经肽Y第二受体基因多态性 |
| Association between obesity and the polymorphism of neuropeptide Y2 receptor gene in children and adolescents |
| Received:January 19, 2009 |
| DOI：10.3760/cma.j.issn.0254-6450.2009.07.012 |
| KeyWord: 神经肽Y第二受体 基因多态性 肥胖 儿童青少年 |
| English Key Word: Neuropeptide Y2 receptor Polymorphism Obesity child and adolescent |
| FundProject:国家自然科学基金(30700668);教育部留学同国人员科研启动基金;科技部“973”项目(2006CB503900). |
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| Abstract: |
| 目的 探讨儿童青少年肥胖与神经肽Y第二受体(ⅣPy2尺)基因rsl047214多态性的相关性, 及其与代谢综合征的关系。方法 选择北京市2030名7～18岁的中小学生进行身体测量、血液生化指标测定和rsl047214多态性检测。结果 NPY2R基因rsl047214多态性的等位基因突变率(r>c)为18.6％;非肥胖组的纯合突变CC基因型频率为3.7％。明显高于肥胖组(1.7％, PP方法 , 用BMI调整后, 不同基因型腰嗣、腰臀比和腰围身高比水平的差异无统计学意义(P>0.05);不同基因型的血脂、血压、血糖指标水平的差异无统计学意义。结论 儿童青少年NPY2R基因rsl047214多态性的突变率与男性肥胖有关, 但与IIIL脂、m压、血糖异常叮能没有显著关联。 |
| English Abstract: |
| Objective To study the relationship between neuropeptide Y2 receptor(NPY2R)gene rsl047214 polymorphism and obesity or metabolic syndrome in Chinese children and adolescents,in order to provide theoretical evidence for obesity contr01.Methods 2030 students at the age from 7 to 18 years were selected in Beijing.Physical indicators, blood pressure。,serum lipids and fasting blood glucose and the rs l0472l4 polymowhism in NPY2R gene were tested for all the subjects.Results The mutation rate of the rsl047214 polymorphism(T>C)was 18.6%and the CC genotype frequency was significantly higher in non.obese subjects(3.7%)than that in obese subjects(1.7%)(P<0.05).The differences of BMI, waist circumference(WC), waist.hip ratio(WHR)and waist-to-height ratio(WtHR)were statistically significant among the subiects with CC genotype having lower BMI, WC, WHR and WtHR than carriers(PConclusion The mutation rate of the 1s1047214 polymorphism in NPY2R gene in Cbinese adolescents was higher than that in foreign populations. Polymorphism seemed to be associated with obesity in males but did not seem to have significant association between polymorphism and other phenotypes of metabolic syndrome. |
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