| 周聪,张瑞岭,杨世昌,李福民.河南省卫辉市农村男性居民酒依赖与酒滥用状况调查[J].Chinese journal of Epidemiology,2009,30(8):867-868 |
| 河南省卫辉市农村男性居民酒依赖与酒滥用状况调查 |
| Epidemiologic survey on alcohol dependence or abuse among male rural habitants in Weihui city,Henan province |
| Received:December 16, 2008 |
| DOI： |
| KeyWord: 酒依赖 酒滥用 流行病学调查 |
| English Key Word: Alcohol dependence Alcohol abuse Epidemiologic survey |
| FundProject:美国中华医学基金会(CMB) |
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| Abstract: |
| 随着我国经济发展,酒生产和消费日益增加,饮酒相关健康问题和社会问题愈加突出,对人类的危害仅次于心脑血管疾病和肿瘤而位居第三[1].为此对河南省卫辉市农村男性居民的酒依赖和酒滥用状况进行流行病学调查,为制定预防和干预措施提供科学依据. |
| English Abstract: |
| Objective To investigate the efficacy and safety of ezctimibe on uncontrolled LDL-C when added to ongoing statin therapy in patients with coronary heart diseases (CHD) and diabetes mellitus (DM). Methods 61 patients with LDL-C level exceeding target goal (<2.07 mmol/L) after 12 weeks' treatment with statins, received ezetimibe in addition to their ongoing statin therapy for 8 weeks. Lipid parameters, alanine aminotransferase(ALT), aspartic aminotransferase(AST) and ereatine kinase(CK) were compared before and after the adding of ezetimibe. Results LDL-C before and after the adding of ezetimibe was (2.74±0.43) mmol/L and (2.19±0.32) mmol/L, respectively (P=0.03) in 61 patients. Ezetimibe added to statin therapy significantly reduced the LDL-C level and TC level by additional 20.1% and 19.1%, respectively (P<0.05). 74%(45/61) patients treated with ezetimibe added to statin reached their target LDL-C goal. No change of TG and HDL-C was observed and no change of AST, ALT and CK was found either. Conclusion Ezetimibe added to statin therapy lowered LDL-C level further and improved the goal attainment in patients with CHD and DM. |
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