| 廖佩花,秦江梅,曾同霞,李锋,蔡金凤,何玲.HPV 16E6、HLA-DR9与新疆哈萨克族人群食管癌交互作用的1：2病例对照研究[J].Chinese journal of Epidemiology,2009,30(9):951-954 |
| HPV 16E6、HLA-DR9与新疆哈萨克族人群食管癌交互作用的1：2病例对照研究 |
| A 1：2 matehed case-controI study on the interaction of HPVl6E6 and HLA-DR9 allele toesophageal cancer in Kazakh ethnicity，Xinjiang |
| Received:February 27, 2009 Revised:August 17, 2007 |
| DOI： |
| KeyWord: 食管癌 人乳头瘤病毒 人类白细胞抗原 病例对照研究 哈萨克族 |
| English Key Word: Esophageal callcer Human papillomavirus Human leukocyte antigen Casecontrol study Kazakh |
| FundProject:国家自然科学基金(30660161)；国家“973”计划f搿期研究专项(2007CB516804) |
| Author Name | Affiliation | E-mail | | LIA0 Peihua | Laboratory of Xinjinng Endemic and Ethnic Diseases, Shihezi Unversity, Shihezi 832002, China | | | QIN Jiangmei | Laboratory of Xinjinng Endemic and Ethnic Diseases, Shihezi Unversity, Shihezi 832002, China | qinjiangmei@yahoo．com.cn | | ZENG Tongxia | Laboratory of Xinjinng Endemic and Ethnic Diseases, Shihezi Unversity, Shihezi 832002, China | | | LI Feng | Laboratory of Xinjinng Endemic and Ethnic Diseases, Shihezi Unversity, Shihezi 832002, China | | | CAI Jinfeng | Laboratory of Xinjinng Endemic and Ethnic Diseases, Shihezi Unversity, Shihezi 832002, China | | | HE Ling | Laboratory of Xinjinng Endemic and Ethnic Diseases, Shihezi Unversity, Shihezi 832002, China | |
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| Abstract: |
| 目的探讨人乳头瘤病毒(HPv)16E6感染、人类白细胞抗原(阳jA)．DR9免疫相关基因对新疆哈萨克族人群食管癌的影响及相互关系。方法采用1：2配比的病例对照研究方法，收集63例哈萨克族食管癌患者，按同性别、同民族、年龄相差≤5岁且居住同一地区等选取对照126例，运用序列特异性聚合酶链反应(PCR．SSP)，检测HPVl6E6的感染率及HLA-DR9等位基因阳性率。交互作用采用分层分析的方法。结果HPVl6E6感染和HLA．DR9等位基因阳性均为哈萨克族食管癌的危险因素，OR值分别为2．67(95％c，：1．38～5．17)和3．83(95％c，：1．48，9．96)。在食管癌组中HLA．DR9等位基因阳性组HPVl6E6感染率为69．2％，明显高于HLA．DR9等位基因阴性组的28．O％(z2=7．57，P=O．006)，OR=5．79(95％c，：1．53～21．87)，对照组中，HLA．DR9等位基因阳性和阴性组的HPVl6E6感染率分别22．2％和16．2％，差异无统计学意义(X2————-O．22，P=0．643)。交互作用提示：HPVl6E6及HLA-DR9等位基因存在交互作用，其危险性高于各单独作用之和。结论HPVl6E6感染及HLA．DR9等位基凶阳性与哈萨克族人群食管癌发生密切相关，两者在食管上皮细胞恶性转化的过程中起到协同作用，共同促进食管癌的发生和发展。 |
| English Abstract: |
| objective To evaluate the role and the association between HPVl6E6 infectionand HLA．DR9 immune．associated gene to esophageal cancer(EC)in Kazakh of Xiniiang．China．Methods A l：2 matched case·control study Was conducted witll 63 cases of EC and 126 controls involved．The controls were matched by sex．nationality。area of residence and age within 5一year difference．HPVl6E6 and HLA-DR9 allele were identified by PCR．SSP．Interaction Was performed to identify risk factors．Results HPVl6E6 infection and HLA．DR9 allele positive status were the risk factors for EC．witll DR values as 2．67(95％C／：1．38-5．17)and 3．83(95％C／：1．48-9．96)respectively． The rate of HPVl 6E6 infection in individuals with HLA-DR9 allele Was different from the ones who were HLA．DR9 allele free(3(2=7．57，P=0．006)，witll f)R value as 5．79(95％C7：1．53-21．87)．In the controls．the rates of HPVl6E6 infection were 22．2％and 16．2％among individuals with HLA-DR9 allele atatus as positive or negative，and without statistically significant difference．Interaction analysis showed there Was all interaction of HPVl6E6 wi吐l HLA-DR9 and were higher than the sum of the two factors presented individually．Conclusion In our study．we found that the HLA．DR9 allele and HPVl6E6 infection had a function of synergy in the process of malignant transformation of esophageal epithelial cells，and iointly promoting the occurrence and development of EC． |
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