| 张勇,高燕,方立群,李亚品,钱全,闫磊,杨华,柏延臣,周蓉,吴浩然,杨红,舒跃龙,曹务春.中国大陆甲型H 1N 1流感扩散模式及预防控制效果定量评价[J].Chinese journal of Epidemiology,2009,30(11):1106-1110 |
| 中国大陆甲型H 1N 1流感扩散模式及预防控制效果定量评价 |
| Pattern on the spread of novel influenza A(HlNl)and quantitative assessment of containment inmainland China |
| Received:June 09, 2009 |
| DOI： |
| KeyWord: 甲型H1N1流感 预防控制 扩散模式 定量评价 |
| English Key Word: Influenza A(HINI) Prevention and control Spread patterns Quantitative assessment |
| FundProject:国家"十-五"科技重大专项(2008ZXl0004-012, 2009ZXl0004-720) |
| Author Name | Affiliation | E-mail | | ZHANG Yong | Beijing Normal University, Beijing 100875, China | | | GAO Yan | 中国疾病预防控制中心病毒病预防控制所病毒基闪工程国家重点实验室 | | | FANG Li-qun | 军事医学科学院微生物流行病研究所病原微生物生物安全国家重点实验室, 100875 | | | LI Ya-pin | 军事医学科学院微生物流行病研究所病原微生物生物安全国家重点实验室, 100875 | | | QIAN Quan | 军事医学科学院微生物流行病研究所病原微生物生物安全国家重点实验室, 100875 | | | YAN Lei | 中国疾病预防控制中心病毒病预防控制所病毒基闪工程国家重点实验室 | | | YANG Hua | Beijing Normal University, Beijing 100875, China | | | BAI Yan-chen | Beijing Normal University, Beijing 100875, China | | | ZHOU Rong | Beijing Normal University, Beijing 100875, China | | | WU Hao-ran | Beijing Normal University, Beijing 100875, China | | | YANG Hong | 军事医学科学院微生物流行病研究所病原微生物生物安全国家重点实验室, 100875 | | | SHU Yue-long | 中国疾病预防控制中心病毒病预防控制所病毒基闪工程国家重点实验室 | |yshu@vip.sina.com | | CAO Wu-chun | 军事医学科学院微生物流行病研究所病原微生物生物安全国家重点实验室, 100875 | caowc@nic.bmi.ac.cn |
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| Abstract: |
| 目的探讨取消边境体温筛查或其他预防控制措施,以及入境人员居家隔离环节这三种场景下中国大陆甲型H1N1流感传播模式.方法根据已有研究资料和数据估计出各传播环节的相关参数,采用蒙特卡罗(Monte Carlo)方法模拟流感的传播过程.结果边境体温筛查在-定程度上能够抑制疫情在国内的传播速度,使3个月后全国累计病例数降低约21.5%(1718例)|疫情的蔓延速度将被延迟约4d.对甲型H1NI患者采取积极防控措施能有效控制疫情的传播和蔓延,使3个月后全国累计病例数比不采取防控措施时降低约93.4%(9万余例)|疫情蔓延至全国的时间被延迟约15 d.如果入境者能够自觉采取居家隔离措施,则控制效果将更为明显,若分别有30%、 60%和90%的人境者自觉采取居家隔离措施,则3个月后全国累计病例数分别可降低约15%(940例)、34%(2230例)和"%(4180例)|且疫情蔓延至全国的时间分别延迟了约4、10、25 d.现有防控措施能够减轻疫情的严重程度,但难以遏制疫情的蔓延.结论中国现有的甲型H1N 1流感预防控制措施效果有效且必要. |
| English Abstract: |
| Objective To study the epidemic tendency of emerging influenza A(H1N1)in mainland China.and to explore the different paRerns of spread on the disease under the following contexts：(1)To stop the temperature screening program at the border areas of the country;(2)To stop measures of prevention and control on those identified cases and their close contacts;(3)To strengthen programs for the foreign immigrants on'home quarantine'.Methods Under relevant parameters and information on the transmission link from difrerent reference data, the patterns of jnfluenza spread were simulated by Monte Carlo method.Results The temperature screening on border could inhibit the transmission of influenza A(HlN1)to some extent, so that after 3 months the cumulative number of cases will be reduced by 21.5%(1718 cases) and transmission speed of influenza A(HlNl)in mainland China will be delayed by about 4 days.Furthermore, taking positive measures of prevention and control could efficiently slow down the epidemic.SO that after 3 months the cumulative number of cases will be reduced by 93.4%(about 90 thousand cases)and it would be delayed by about 15 days if influenza A(HINI)spreads to the whole country.In addition.if the immigrants were able to practise quarantine measures consciously by themselves at home the effect of prevention and control against influenza A(HlNl)would be more significant.If 30%.60%and 90%of immigrants would take quarantine measures home consciously.after 3 months the cumulative number of caSes will be reduced by about 15%(about 940 cases). 34%(about 2230 cases)and 64%(about 4180 cases), respectively. Also, influenza A(HlN1)spreads to the whole country will be delayed by about 4 days, 10 days and 25 days, respectively.It is difficult to curb fully the development of the epidemic by taking existing control measures,and influenza A(H1N1)may spread to almost all provinces after about 3 months. Conclusion The effects of existing prevention and control measures were objectively assessed and the Results showed the necessity and effectiveness of these measures against the transmission of influenza A(H1N1).in the mainland of China. |
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