细胞色素P4501A1基因多态性与食管癌易感性关系的Meta分析

代丽萍; 王彦平; 吴晓冰; 王凯娟; 吕全军

Abstract

代丽萍,王彦平,吴晓冰,王凯娟,吕全军.细胞色素P4501A1基因多态性与食管癌易感性关系的Meta分析[J].Chinese journal of Epidemiology,2009,30(11):1198-1202

细胞色素P4501A1基因多态性与食管癌易感性关系的Meta分析

Study on the association of cytochrome P450 polymorphisms and the risk of esophageal cancer：a meta-analysis

Received:March 18, 2009

DOI：

KeyWord: 食管癌 CYPlAl 基因多态性 Meta分析

English Key Word: Esophageal cancer CYPlAl Gene polymorphism Meta-analysis

FundProject:国家自然科学基金(30872181)|教育部"211工程"项目|河南省科技攻关计划项目(031161200)

Author Name	Affiliation	E-mail
DAI Li-ping	College of Public Health, Zhengzhou University, Zhengzhou 450001, China
WANG Yan-ping	河南省农业职业学院食品科学系, 450001
WU Xiao-bing	College of Public Health, Zhengzhou University, Zhengzhou 450001, China
WANG Kai-juan	College of Public Health, Zhengzhou University, Zhengzhou 450001, China
LV Quan-jun	College of Public Health, Zhengzhou University, Zhengzhou 450001, China	lqjnutr@zzu.edu.cn

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Abstract:

目的探讨细胞色素P4501AI(CYPIAl)MSpl和lle/Val位点基因多态性与食管癌发生的关系.方法采用Meta分析方法,对国内外1997-2008年采用病例对照方法研究CYPIAl Mspl和llelVal基因多态性与食管癌发生关系的16篇(Mspl 8篇,lle/Val 14篇)文献,采用显性模型(即突变基因型与野生型比较)进行综合定量分析,然后按病理分型(鳞癌/腺癌)分亚组进行分析.结果综合分析CYPlAl Mspl突变基因型(TC+CC)与食管癌发生无统计学关联(OR=1.17,95%CI :0.82-1.66),亚组分析亦未发现CYPIAl Mspl突变基因型与食管鳞癌(OR=1.17,95%CI:0.82-1.69)和食管腺癌(OR=1.39,95%CI: 0.67-2.09)的统计学关联|携带CYPIAl突变基因型(Ile/Val+Val/Val)的个体发生食管癌的危险性是野生型的1.39倍(OR=1.39,95%CI:1.07～1.80)|亚组分析显示突变基因型与食管鳞癌发生的易感性相关但与食管腺癌无关联,OR值分别为1.43(95%CI:1.07～1.91)和1.20(95%CI :0.62～2.30).结论CYPlAl lle/Val位点突变基凶型可增加食管鳞癌发生的危险性,CYPIAl Mspl位点基因多态性与食管癌无关联.

English Abstract:

Objective To examine the association between CYPlAI polymorphisms(Mspl and lle/Val)and esophageal cancer(EC)by systematically reviewing the risk of the original studies.Methods Data from 16 papers(8 for Mspl,14 for lle/VaL)regarding case.control studies on the association of cytochrome P450 polymorphisms and risk of esophageal cancer was analyzed by dominant model(variant genotype vs. wild-type genotype)through meta-analysis.Stratified analysis was carried out according to the pathological types. Results In systematicaI analysis.CYPIAI MspI variant genotype(TC+CC)had no association with ECrisk(OR=1.17.95%ORResults were observed in esophageal squamous-cell carcinoma(ESCC)(OR=1.17, 95%CI：0.82-1.69)and esophageal adenocarcinoma(EAC)(OR= 1.39.95%CI0.67-2.09).Individuals with the CYPlAl Ile/Val variant genotype(Ile/Val+Val/Val)had an increased risk for EC.when comparing with wild type(Ile/Ile), with an OR of l.39(95%CI：1.07-1.80).CYPIAI Ile/Val variant genotype couldincrease the risk of ESCC (OR=1.43.95%CI：1.07-1.91)but no significant association was found with EAC(OR=1.20, 95%CI:0.62-2.30). Conclusion CYPIAI gene polymorphism Ile/Val might have played a role in the development of ESCC but CYPIAI Mspl polymorphism might not be associated with the susceptibility of EC.

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