脂联素基因多态性与北方汉族人群缺血陛脑卒中易感性关系研究

陈小良; 程锦泉; 张仁利; 刘建平; 李晓霞; 童叶青; 耿艺介

Abstract

陈小良,程锦泉,张仁利,刘建平,李晓霞,童叶青,耿艺介.脂联素基因多态性与北方汉族人群缺血陛脑卒中易感性关系研究[J].Chinese journal of Epidemiology,2010,31(2):129-132

脂联素基因多态性与北方汉族人群缺血陛脑卒中易感性关系研究

Study on the relationship between polymorphism of adiponectin gene and risk of ischemic stroke　among Han population in the Northern parts of China

Received:July 21, 2009

DOI：

KeyWord: 缺血性脑卒中脂联素基因多态性

English Key Word: Ischemic s仃oke Adiponectin Polymorphism

FundProject:国家自然科学苯会(30771852)

Author Name	Affiliation	E-mail
CHEN Xiao-liang	Department of Epidemiology and Statistics, the College of Public Health of Zhengzhou University, Zhengzhou 450001, China
CHENG Jin-quan	Shenzhen Center for Disease Control and Prevention	cjinquan@vip.sohu.cA)in
ZHANG Ren-li	Shenzhen Center for Disease Control and Prevention
LlU Jian-ping	Shenzhen Center for Disease Control and Prevention
LI Xiao-xia	Mudanjiang Medical University
TONG Ye-qin	Shenzhen Center for Disease Control and Prevention
GENG Yi-jiei	Shenzhen Center for Disease Control and Prevention

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Abstract:

目的探讨脂联素基因多态性与北方汉族人群缺IIIL性脑卒中易感性的关系。方法采用荧光定量PCR的TaqMan探针方法检测357例缺血性脑卒中首发病例及345名健康对照的脂联素基冈(rs2241766、rs266729)多态性，用logistic回归分析计算符基因型与缺血性脑卒中的相关性。结果总体人群中rs2241766等位基因T>G突变增加r缺血性脑卒中的易感性(OR=1.55，P=0.01)；调整各因素后，多因素logistic回归分析仍为缺血性脑卒中的危险因素(OR----1.55，P=0.00)。rs266729多态性与总体人群缺血性脑卒中易感性无关(OR=1.13，P=0.57)，但在女性中GG纯合突变增加了缺血性脑卒中的易感性(OR=3.25，P=0.04)。结论rs2241766基因多态性与北方汉族总体人群缺血性脑卒中的易感性相关；rs266729等位基凶GG纯合突变可能是北方汉族女性缺血性脑卒中易感性的危险因素。

English Abstract:

Objective To explore the association between polymorphisms of adiponectin gene and the risk of ischemic stroke in Han population from the Northern parts of China.Methods TaqMan probe of RT-PCR was applied to detect the genotype frequency of single nucleotide polymorphism(SNPs)(rs266729 and rs224 l 766)of adiponectin gene in 357 ischemic stroke eases who developed the episode at first time and with 345 healthy controls.Logistic regression analysis was used to evaluate the relationship of each genotype of SNPs and ischemic stroke.ResultsMutation of rs2241766(T>G)increased the risk of ischemic stroke among a11 the samples(OR=1.55.P=0.01)and it was still the risk factor of ischemic stroke when analyzed by multi-factors logistic regression after each factor was adjusted(OR=1.55，P=0.00).The polymorphism of rs266729 was not related to the risk ofischemic stroke among all the samples(O尺=1.13，P=0.57).However，the genotype GG of rs266729 increased the risk of ischemic stroke among female population(OR=3.25。P=0.04).Conclusion The variance of rs2241766 in adiponectin gene was related to the risk of ischemic stroke in Han population from the Northern parts of China and the genotype GG of rs266729 could possibly increase the risk of ischemic stroke in women of Han population from the Northern parts of the counlYy.

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