| 张玲,孟开,张杰,刘超,宫木幸一,村松正明.CYP3A5基因多态性与摄盐水平的交互作用对日本男性血压的影响[J].Chinese journal of Epidemiology,2010,31(8):952-953 |
| CYP3A5基因多态性与摄盐水平的交互作用对日本男性血压的影响 |
| The interactive effect between CYP3A5/A6896Gpolymorphism and salt intake level on blood pressure in Japanese male |
| Received:March 31, 2010 |
| DOI： |
| KeyWord: 细胞色素P450酶系3A5 基因多态性 摄盐水平 交互作用 |
| English Key Word: CYP3A5 Polymorphism Salt intake level Interaction |
| FundProject:国家自然科学基金(30800949);北京市科技新星项目(2009A47);北京市优秀人才培养资助个人项目(20081D0501800211);国家教育部归国留学启动基金([2009]8) |
| Author Name | Affiliation | E-mail | | Zhang Ling | Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine, Capital Medical University, Beijing 100069,China | zlflyepi@cc'IllU.edu.cn | | Meng Kai | School of Health Management and Education, Capital Medical University | | | Zhang Jie | Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine, Capital Medical University, Beijing 100069,China | | | Liu Chao | Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine, Capital Medical University, Beijing 100069,China | | | Gong Muxing Yi | Department of Clinical Research and Informatics, Research Institute, International Medical Center of Japan | | | Cun Songzheng Ming | Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University ,Japan | |
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| Abstract: |
| 细胞色素P450酶系(Cytochrome P450，CYP)3A5酶参与原发性高血压的致病机制，CYP3A5基因可能是导致盐敏感性高血压的重要候选基因之一。本研究日本男性人群中探讨CYP3A5/A6986G多态性与血压的关联，研究基因型与个体摄盐水平的交互作用对血压的影响，旨在通过探索基因一环境交互作用对血压的影响，分析CYP3A5基因对盐敏感性高血压的作用。 |
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