| 刘涛,王辉,邱泉,谭荔荔,陈崴,余学清,孙小丽,陈维清.中心型肥胖在吸烟与p细胞功能关系中的
中介效应[J].Chinese journal of Epidemiology,2010,31(9):988-991 |
| 中心型肥胖在吸烟与p细胞功能关系中的
中介效应 |
| Mediation of abdominal obesity on the association between cigarette smoking and β-cell function |
| Received:April 02, 2010 |
| DOI： |
| KeyWord: 中心型肥胖 吸烟 B细胞功能 中介效应 |
| English Key Word: Abdominal obesity Cigarette smoking β-cell function Mediation effect |
| FundProject:广州市医药卫生科技重大项目资助(2005-ZDa-001) |
| Author Name | Affiliation | E-mail | | LIU Tao | Department of Medical Statistics and Epidemiology School of Public Health, Sun Yat-sen University, Guangzhou 510080, China | | | WANG Hui | Department of Medical Statistics and Epidemiology School of Public Health, Sun Yat-sen University, Guangzhou 510080, China | | | QIU Quan | Department of Medical Statistics and Epidemiology School of Public Health, Sun Yat-sen University, Guangzhou 510080, China | | | TAN Li-li | Department of Medical Statistics and Epidemiology School of Public Health, Sun Yat-sen University, Guangzhou 510080, China | | | CHEN Wei | Department of Nephrology, the First Affiliated
Hospital of Sun Yat-sen University
| | | YU Xue-qing | Department of Nephrology, the First Affiliated
Hospital of Sun Yat-sen University
| | | SUN Xiao-li | Department of Gynecology, Guangdong Women’s and Children’S
Hospital | | | CHEN Wei-qing | Department of Medical Statistics and Epidemiology School of Public Health, Sun Yat-sen University, Guangzhou 510080, China | chenwq@mail.sysu.edu.cn |
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| Abstract: |
| 目的 了解吸烟量对β细胞功能的影响,并探讨中心型肥胖在吸烟量与β细胞功能关系中的中介效应.方法 2006-2007年在广州和珠海市参加慢性病筛查研究的社区居民中选择1440名吸烟者为研究对象,调查人口学特征和每天吸烟量,测量腰臀比,并检测空腹血清C肽浓度.结果 控制混杂因素后,以每天吸烟1～10支者为对照组,每天吸烟11～20支者和＞20支者出现较高C肽浓度(大于中位数)的OR值分别为1.53(95%CI:1.22～1.90)和1.92(95%CI:1.32～2.79).吸烟量与中心型肥胖成正相关(a=0.21),并且控制了中心型肥胖的作用后(b=0.94),吸烟量与β细胞功能的关联仍然具有统计学意义(c'=0.33);中心型肥胖对吸烟量的中介效应值为37.54%.结论 吸烟可能是β细胞功能受损的危险因素,并且中心型肥胖可能是二者关联中的一个部分中介因素. |
| English Abstract: |
| Objective To confirm the effect of cigarette smoking on β-cell function, and further investigate the mediation effect of abdominal obesity. Methods Participants would include 1440 Chinese smokers who had participated in a community-based chronic disease screening project in Guangzhou and Zhuhai from 2006 to 2007. They were interviewed with structured questionnaire on their socio-demographic status and smoking behaviors. Waist-to-hip ratio (WHR) and fasting serum C-peptide concentration were also measured. Results After adjustment for the potential confounding factors, when compared with smokers with consumption 1-10 cigarettes/day, smokers with consumption of 11-20 cigarettes/day (adjusted OR=1.53, 95%CI: 1.22-1.90) or ＞20 cigarettes/day (adjusted OR=1.92, 95%CI: 1.32-2.79) had significant higher risks to get C-peptide concentration larger than its median. Furthermore, 37.54% of the effect of cigarette smoking on C-peptide concentration was partially mediated by abdominal obesity. Conclusion Cigarette smoking might be a risk factor for β-cell dysfunction and abdominal obesity. |
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