新疆哈萨克族和汉族代谢综合征患者脂蛋白脂酶基因HindⅢ、S447X多态性的相关分析

郭淑霞; 杨志明; 郭恒; 张景玉; 唐景霞; 芮东升; 马儒林

Abstract

郭淑霞,杨志明,郭恒,张景玉,唐景霞,芮东升,马儒林.新疆哈萨克族和汉族代谢综合征患者脂蛋白脂酶基因HindⅢ、S447X多态性的相关分析[J].Chinese journal of Epidemiology,2010,31(9):992-996

新疆哈萨克族和汉族代谢综合征患者脂蛋白脂酶基因HindⅢ、S447X多态性的相关分析

Association of lipoprotein lipase gene Hind Ⅲ and S447X polymorphisms in metabolic syndrome patients among Kazakh and Han ethnics from Xinjiang

Received:December 21, 2009

DOI：

KeyWord: 代谢综合征脂蛋白脂酶基因多态性哈萨克族汉族

English Key Word: Metabolic syndrome Lipoprotein lipase Gene polymorphism Kazakh Han race

FundProject:"十一五"国家科技支撑计划(2009BAI82B04);新疆生产建设兵团国际科技合作项目(2009YD33)

Author Name	Affiliation	E-mail
GUO Shu-xia	Department of Public Health of Medical College, Shihezi University, Shihezi 832002, China；	hpge888@sina.com
YANG Zhi-ming	Department of Public Health of Medical College, Shihezi University, Shihezi 832002, China；Outpatient Department of International Relationship College of the PLA, Jiangsu, Nanjing
GUO Heng	Department of Public Health of Medical College, Shihezi University, Shihezi 832002, China；
ZHANG Jing-yu	Department of Public Health of Medical College, Shihezi University, Shihezi 832002, China；
TANG Jing-xia	Department of Public Health of Medical College, Shihezi University, Shihezi 832002, China；
RUI Dong-sheng	Department of Public Health of Medical College, Shihezi University, Shihezi 832002, China；
MA Ru-lin	Department of Public Health of Medical College, Shihezi University, Shihezi 832002, China；

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Abstract:

目的探讨脂蛋白脂酶(LPL)基因Hind Ⅲ、S447X多态性与新疆哈萨克族和汉族人群代谢综合征(MS)及其组分的关系.方法应用聚合酶链反应-限制性片段长度多态法检测802名研究对象(哈萨克族和汉族MS各200名和对照各201名)的LPL基因Hind Ⅲ、S447X基因多态性.结果 (1)汉族MS组H+H-/H-H-基因型(32.50%vs.47.76%)、H-等位基因(18.00%vs.28.86%)、SX/XX基因型(8.00%vs.22.39%)、X等位基因(4.00%vs.12.44%)频率低于对照组,P值均＜0.01.(2)哈萨克族MS组H+H-/H-H-基因型(33.50%vs.45.80%)、H-等位基因(22.00%vs.28.60%)、SX/XX基因型(10.50%vs.22.90%)、X等位基因(5.50%vs.12.44%)频率低于对照组,P值均＜0.01.(3)LPL基因Hind Ⅲ、S447X基因型和等位基因频率在哈萨克族和汉族MS组间的差异无统计学意义(P值均＞0.05).(4)H+H-/H-H-基因型携带者、SX/XX基因型携带者腰围、SBP、DBP、甘油三酯、空腹血糖水平分别较H+H+基因型携带者和SS基因型携带者低,高密度脂蛋白胆固醇水平分别高于H+H+基因型携带者和SS基因型携带者,差异均有统计学意义(P值均＜0.05).(5)随着MS组分异常的增多,H+H+、SS基因型携带率均有不断增加的趋势.结论 LPL基因Hind Ⅲ、S447X多态性与MS的发病风险相关,其中H+H-/H-H-基因型、H-等位基因、SX/XX基因型、X等位基因可能是MS的保护因素,H+H-/H-H-和SX/XX基因型对MS各组分产生有益的影响,且随着MS组分异常个数的增加,H+H+、SS基因型携带率也相应增加

English Abstract:

Objective To investigate the association of lipoprotein lipase gene Hind Ⅲ and S447X polymorphisms with metabolic syndrome among Kazakh and Han ethnicities in Xinjiang.Methods PCR-RFLP was used to detect 802 subjects' lipoprotein lipase Hind Ⅲ and S447Xgenotypes (including 201 controls and 200 metabolic syndrome patients in Kazakh and Han ethnicities, respectively). Results (1) Frequencies of H + H-/H-H- genotype (32.50% vs.47.76%), H- allele( 18.00% vs. 28.86%), SX/XX genotype (8.00% vs. 22.39%) and X allele (4.00%vs. 12.44% ) for metabolic syndrome in Hah ethnicity were all significantly lower than those in controls (P＜ 0.01 ). (2) The frequencies of H + H-/H-H- genotype (33.50% vs. 46.80% ), H- allele (22.00% vs. 28.60%), SX/XX genotype (10.50% vs. 22.90%) and X allele (5.50% vs. 12.44% ) in patients with metabolic syndrome in Kazakh were all significantly lower than those for controls (P＜0.01). (3) The frequencies of lipoprotein lipase gene Hind Ⅲ and S447X genotypes and alleles in Kazakh were not significantly different from Han (all P＞0.05). (4)The levels of waist circumference, systolic blood pressure, diastolic blood pressure, triglyceride and FPG in H + H-/H-H- and SX/XX genotype were significantly lower than those in H + H + and SS genotype.HDL-C was significantly higher than that in H + H + and SS genotype (P＜0.05). (5) The frequencies of H + H + and SS genotype increased along with the increase in number of metabolic syndrome component. Conclusion The lipoprotein lipase gene Hind Ⅲ and S447X polymorphisms were associated with metabolic syndrome risk in Kazakh, and H + H-/H-H- genotype, H- allele, SX/XX genotype and X allele might have served as protective factors of metabolic syndrome. H + H-/H-H- and SX/XX genotype seemed to have had beneficial effects for all the metabolic syndrome components, and the frequencies of H + H + and SS genotype were increasing along with the increase of number in the metabolic syndrome components.

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