液体总摄人量和小便次数与上海市区居民膀胱癌危险性的关系

张薇; 项永兵; 方茹蓉; 程家蓉; 袁剑敏; 高玉堂

Abstract

张薇,项永兵,方茹蓉,程家蓉,袁剑敏,高玉堂.液体总摄人量和小便次数与上海市区居民膀胱癌危险性的关系[J].Chinese journal of Epidemiology,2010,31(10):1120-1124

液体总摄人量和小便次数与上海市区居民膀胱癌危险性的关系

TotaI fluid intake.urination frequency and risk of bladder cancer：a population-based case.control study in urban Shanghai

Received:May 20, 2010 Revised:June 20, 2012

DOI：10.3760/cma.j.issn.0254-6450.2010.10.O11

KeyWord: 膀胱肿瘤吸烟液体总摄人量小便次数病例对照研究

English Key Word: Bladder neoplasms Smoking Total fluid intake Urination frequency Casecontrol study

FundProject:世界卫生组织．瑞典国际开发合作署资助项目(wP/2006/(：HN/HIv/1．2/002/03．03．AW．01)；国家高科技“863”课题资助项目(2006AA027．418)

Author Name	Affiliation	E-mail
ZHANG Wei	Department of Epidemiology, Cancer Institute of Shanghai Jiaotong University, Shanghai Cancer Institute, Shanghai 200032, China	ybxiang@shsci.Org
XIANG Yong-bing	Department of Epidemiology, Cancer Institute of Shanghai Jiaotong University, Shanghai Cancer Institute, Shanghai 200032, China
FANG Ru-rong	Department of Epidemiology, Cancer Institute of Shanghai Jiaotong University, Shanghai Cancer Institute, Shanghai 200032, China
CHENG Jia-rong	Department of Epidemiology, Cancer Institute of Shanghai Jiaotong University, Shanghai Cancer Institute, Shanghai 200032, China
YUAN Jian-min	Division of Epidemmlogy and Community Health.School of Public Health, University of Minnesota, USA
GAO Yu-tang	Department of Epidemiology, Cancer Institute of Shanghai Jiaotong University, Shanghai Cancer Institute, Shanghai 200032, China

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Abstract:

目的探讨液体总摄人量和小便次数与上海市区居民膀胱痈危险性的关系。方法采用伞人群病例对照研究，共调企1996年1月1日至1998年12月31日期间诊断的上海市区膀胱癌新发病例608例，以及性别、年龄配对的人群对照607名。采用非条件logistic回归模型,调整可能的混杂因素，估计液体总摄人量和小便次数与膀胱癌发生的OR值及95％CI(a=0.05)。结果每天液体总摄人量及夜晚(即睡眠时间内)小便次数与膀胱癌发生的危险性无统计学意义的相关。白昼(即1F睡眠时间内)通常小便次数与膀胱癌危险性呈负相关。调整年龄、性别、是否吸烟、液体总摄入量及其他因素后，与白昼通常小便次数≤3次者相比，小便次数为4、5及>16次者的OR值分别为0.72(95％C1：0.49～1.05)、0.60(95％CI：0.41～0.87)和0.62(95％CI：0.43-0.90)，趋势检验有统计学意义(P=0.014)。与白昼通常小便次数≤3次者相比，白昼通常小便次数≥6次的吸烟者和不吸烟者的OR值分别为0.72(95％C／：0.45-1.15)和0.46(95％CI：O.25～0.87)。与每天液体总摄入量≤750 ml且白昼通常小便次数≤3次者相比，每天液体总摄人量>1500 ml且白昼通常小便次数>／6次者膀胱癌的危险性降低了57％，有统计学意义的相火性。结论不憋尿且多饮水，尤其不吸烟者可以降低膀胱癌发牛的危险性。

English Abstract:

Objective To evaluate the association between total fluid intake and the time of urination per day and the risk of bladder cancer.Methods A population-based case-control study was conducted in urban Shanghai.China.during January l 996 to December 1 998.The study included 608 incident cases of bladder cancer and 607 age.and sex.matched controls.Unconditional logistic regression models were used to estimate the odds ratios(ORs)and their corresponding 95％ confidence intervals(95％CIs)for bladder cancer associated with frequency of urination，after adjusted for age。gender。smoking status，history of occupation with high risk，history of bladder infections.body mass index and other confounding factors.The level of statistical significance was set at 0.05(two.sided).Results No significant fiend was observed for the association between toml fluid intake.time of nighttime urination and the risk of bladder cancer.Increasing time of urination during daytime was associated with decreased risk of bladder cancer(P for trend=0.014).ORs (95％C／s)for subjects who voided 4 times，5 times and 6 or more times per day[O.72(0.49-1.05)， 0.60(0.4 1一O.87)and 0.62(0.43-0.90)，respectively I，when compared with those with less than 4 times per day after adjustment of confounding factors.Data showed that smokers and nonsmokers who voided at least 6 times per day had the O尺s of 0.72(95％Cy：0.45-1.15)and 0.46(95％(V： 0.25一O.87)when compared to their counterparts who voided 3 times or less per day during the daytime.Subjects who urinated at least 6 times per day and consumed more than 1 500 ml of total fluid per day experienced a significant 57％reduction iu risk compared to subjects who urinated 3 times or less and consumed less than 750 ml of total daily fluid intake.Conclusion Increasedurination frequency and total fluid intake，especially among those who never smoked might be associated with a reduced risk of bladder cancer.

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