浙江省人和家畜蜱媒传染病血清流行病学调查

柴程良; 陆群英; 孙继民; 姜理平; 凌锋; 张丽娟; 郑寿贵; 张宏; 葛君华

Abstract

柴程良,陆群英,孙继民,姜理平,凌锋,张丽娟,郑寿贵,张宏,葛君华.浙江省人和家畜蜱媒传染病血清流行病学调查[J].Chinese journal of Epidemiology,2010,31(10):1144-1147

浙江省人和家畜蜱媒传染病血清流行病学调查

Sero-epidemiologic investigation on tick-borne diseases of humans and domestic animals in Zhejiang province

Received:May 27, 2010 Revised:May 28, 2012

DOI：10.3760/cmaj.issn.0254-6450.2010.10.016

KeyWord: 克次体巴尔通体蜱媒传染病血清流行病学

English Key Word: Rickettsiae Banonella Tick-borne diseases Sero-epidemiology

FundProject:中美新发和再发传染病合作项目(1U2GGH000018-01)；浙江省医药卫生科技项目(2009A045)

Author Name	Affiliation	E-mail
CHAI Cheng-liang	Zhejiang Provincial Center for Disease Control and Prevention.Hangzhou 31005l, China	chlchai@yahoo.Cn
Lu Qun-ying	Zhejiang Provincial Center for Disease Control and Prevention.Hangzhou 31005l, China
SUN ji-min	Zhejiang Provincial Center for Disease Control and Prevention.Hangzhou 31005l, China
JIANG Li-ping	Zhejiang Provincial Center for Disease Control and Prevention.Hangzhou 31005l, China
LING Feng	Zhejiang Provincial Center for Disease Control and Prevention.Hangzhou 31005l, China
ZHANG Li-juan	Chinese Center for Disease Control andPrevention
ZHENG Shou-gui	Jindong Center for Disease Control and Prevention of Jinhua
ZHANG Hong	Anji Center for DiseaseControl and ention
GE Jun-hua	Tiantai Center for Disease Control and Prevention

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Abstract:

目的了解浙江省农村人群与主要家畜蜱媒传染病病原体感染的情况。方法按地理位置和蜱媒传染病病原体历史检测情况，选择浙西北丘陵区的安吉县、浙中丘陵盆地区的金东区和浙东盆地低山区的天台县为调查点，采集3个调查点农村人群和家畜血标本，以间接免疫荧光法检测黑龙江立克次体、恙虫病东方体、莫氏立克次体、嗜吞噬无形体、杳菲埃立克体、巴尔通体、海南立克次体和贝纳柯克斯体8种常见蜱媒传染病病原体IgG抗体。结果 3个调查点共检测683份血清标本，包括579份人标本和104份家畜标本(牛53份、羊5l份)，不同地区恙虫病东方体、奠氏立克次体、查菲埃立克体、贝纳柯克斯体4种病原体抗体阳性率差异有统计学意义(P值均等于0.000)。人血清标本8种病原体IgG抗体均检出，阳性率最高的分别是莫氏立克次体 (20.7％)、巴尔通体(10.9％)和贝纳柯克斯体(5.5％)，其中莫氏立克次体抗体阳性率随年龄增长而增加。家畜血清标本除嗜吞噬无形体外其余7种病原体IgG抗体均枪出。阳性率最高的是莫氏立克次体(69.2％)、巴尔通体(51.0％)和海南立克次体(22.1％)，不同家畜抗体阳性情况不同。结论浙江省不同地区农村人群与家畜中广泛存在多种蜱媒传染病病原体的感染，特别是莫氏立克次体、巴尔通体、海南立克次体和贝纳柯克斯体抗体阳性率较高。

English Abstract:

Objective To investigate the seroprevalence of tick-borne diseases in humans and domestic animals from rural areas of Zhejiang province.Methods Anji county.Jindong district and Tiantai county were selected for samples collection according to their geographic locations and historical prevalence of tick.borne diseases.Blood samples of humans and domestic animals were collected in the three sites.An jndirect immlJxlo.fluorescent antibody test was used to determine the presence of IgG antibodies of Rickettsiae heilongjiangii，Orientia tsutsugamushi，R.typhi，Anaplasma phagocytos，Ehrlichia chaffeensis，Bartonella，R.hainan and CoxieZla burnetii in these samples. Results Six hundred and eighty.three blood samples including 579 from humans and 1 04 from domestic animals(53 from cattles and 5l from sheep)were collected from the three sites.Antibody positive rates of Orientia tsutsugamushi，R.typhi，Ehrlichia chaffeensis and Coxiella burnetii were significantly difierent between these sites.IgG from all the 8 pathogens were detected in samples from humans.It was found that the sero.prevalence rates of R typhi.Bartonella and c.burnetii(20.7％。 1 0.9％，5.5％)of adults were higher than those of other Rickettiae under investigation.The seroprevalence of R typhi increased along with age.IgG from the 7 pathogens were detected insamples from domestic animals except for Anaplasma phagocytos.The sero.prevalence rates of R.typhi，Bartonella and R hainan(69.2％，5 1.0％，22.1％)of adults were higher than those of other Rickettsiae investigated.Conclusion Tickobome diseases did spread widely in humans and domestic animals from different rural areas of Zhejiang province.The sero.prevalence rates of R.typhi. B.henselae.R，hainan and C.burnetii were higher than that from other pmhogens.

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