| 李胜利,祖茂衡,陆召军.布加综合征研究进展[J].Chinese journal of Epidemiology,2010,31(10):1192-1195 |
| 布加综合征研究进展 |
| A review on the research status and trends of Budd-Chiari syndrome |
| Received:March 24, 2010 |
| DOI：10.3760/cma.j.issn.0254-6450.2010.10.027 |
| KeyWord: 布加综合征 流行病学 JAK2点突变 |
| English Key Word: Budd-Chiari syndrome Epidemiology JAK2 point mutation |
| FundProject:贵州省科技基金及贵州省省长基金资助项目(2055) |
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| Abstract: |
| 布加综合征(Budd.Chiari syndrome，BCS)是由各种原因引起的较大肝静脉或肝段下腔静脉部分/完全梗阻性肝静脉——下腔静脉血液回流障碍，导致淤m性门静脉高压症和下腔静脉高压症两大综合征。 |
| English Abstract: |
| Objective To identify the mortality-related factors in patients undergoing maintenance hemodialysis.Methods One hundred and seven long-term hemodialysis patients having suffered from chronic glomerulonephritis and received hemodialysis treatment in the hemodialysis center of the Friendship Hospital during February 1990 to February 2002 were selected to take part in a retrospective study. Survival analysis was done using Life Tables study. Cox regression analysis was used to find factors related to risk. Patients were divided into two groups according to the clinical value of the factors which showed statistical significance in Cox regression analysis. Survive rates were compared between two groups on Gehan test.Results Among the 107 patients, 22 died (15.3%)and 85 survived (84.7%)during the follow-up period. Cumulative survival rates of 5 years and 10 years were 79.91% and 64.36% respectively. Prognostic factors would include age (P 0.001), blood urea nitrogen (BUN, P=0.004), serum creatinine (SCr, P=0.001), value of plasma calcium multiplied by plasma phosphate (P=0.019), and KT/V (P=0.001), which were all tested during the third dialysis month. The Hazard Ratios (HR) were 1.107 (95% Confidence Interval,95% CI : 1.049- 1.168), 0.951(95% CI : 0.918- 0.984), 0.727(95% CI : 0.599- 0.883), 1.025(95% CI : 1.004- 1.046), and 0.013(95% CI : 0.001- 0.161), respectively. The survival rates between two groups were significant different (age≥60 years group vs 60 years group P=0.000 6, BUN≥ 28.6 mmol/L vs 28.6 mmol/L group P=0.041 5, SCr≥884 μmol/L vs 884 μmol/L group P=0.014 6, value of plasma calcium multiplied by plasma phosphate ≥40 vs 40 group P=0.046 4, KT/V≥ 1.30 vs 1.30 group P=0.021 5).Conclusions The mortality related prognostic factors of maintained hemodialysis patients seemed to include age, BUN, SCr, value of plasma calcium multiplied by plasma phosphate, and KT/V, which were all tested during the third dialysis month. Among them, age and the value of plasma calcium multiplied by plasma phosphate were risk factors of death, while the others were protective factors. |
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