| 姜梅,崔伟红,李波,王日雷,宫连风,刘娟.烟台市戊型肝炎流行特征及危险因素分析[J].Chinese journal of Epidemiology,2010,31(12):1417-1420 |
| 烟台市戊型肝炎流行特征及危险因素分析 |
| Epidemiological study on risk factors of hepatitis E in Yantai Shandong province |
| Received:October 25, 2010 |
| DOI：10.3760/cma.j.issn.0254—6450.2010.12.022 |
| KeyWord: 戊型肝炎 流行病学 危险冈素 |
| English Key Word: Viral hepatitis E Epiderniology Risk factors |
| FundProject: |
| Author Name | Affiliation | E-mail | | Jiang Mei | Center for Disease Control and Prevention,Yantai 264003,China | ytjiangmei@163.com | | Cui Weihong | Center for Disease Control and Prevention,Yantai 264003,China | | | Li Bo | Center for Disease Control and Prevention,Yantai 264003,China | | | Wang Yuelei | Center for Disease Control and Prevention,Yantai 264003,China | | | Gong Lianfeng | Center for Disease Control and Prevention,Yantai 264003,China | | | Liu Juan | Center for Disease Control and Prevention,Yantai 264003,China | |
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| Abstract: |
| 目的探讨烟台市戊型肝炎(HE)流行特征及发病危险因素。方法根据法定传染病报告系统分析烟台市2005--2009年HE疫情资料；采用ELISA检测2028人HE抗体水平，用巢式RT-PCR检测患者粪便，阳性者开展戊肝病毒(HEY)基因测序；采取病例对照研究方法，对HE危险因素进行调查分析。结果烟台市HE呈散在发病，年均发病率为5．70/10万，春季为流行季节，发病年龄以>40岁中老年人为主，地区分布呈现沿海岸线分布特点，职业以农民较多；血清流行病学调查显示，人群感染率25．10％；病毒序列分析表明患者的HEV基因型为4型，健康体检HEVIgM阳性者HEV基因为l型。单因素分析显示，食海产贝类、居住环境、不良生活习惯等均为HE发病的危险因素；多因素分析显示，食海产贝类、外出就餐、饮酒、喝生水仍为发病的独立危险因素。结论烟台市HE发病率将维持在较高水平，但不会出现大范围暴发或流行，发病人群仍以农民为主。 |
| English Abstract: |
| Objective To study the prevalent characteristics and risk factors of viral hepatitis E in Yantai and the relative for strategy on viral hepatitis E control in the area．Methods Data on viral hepatitis E incidence reported by the Notifiable Infectious Disease Reporting System in 2005—2009 was analyzed．2028 persons were chosen for hepatitis E virus fHEV)antibody detection by enzyme linked immunosorbent assay method．RT_nPCR method was applied to obtain the sequence of HEV in HEV cases．A case—control study Was used to identify the risk factors of HEV infection． Results The distribution of HEV cases was sporadic in Yantai．and the annual incidence rate was 5．70/l 00 000．with spring as the prevalent season．Farmers were the main population involved and with those over the age of 40．Regional distribution was mainly along the coastline．Data from the sequential analysis showed that gene type of local patients Was type 4 and healthy person whose HEV-IgM was positive Was type 1．Finding from the case-control study suggested that eating seafoods， living condition in the households and unhealthy habits played important roles in the infection of HEV． Results from multiple logistic regression showed that eating seafood．with eat．out history，drinking alcohol and an—boiled water were the main risk factors in the infection of HEv．Conclusion The level of HE in Yantai will maintain in a high level．but there iS no chance of epidemic outbreak of HE in large range．Population of incidence mainly concentrates on farmers． |
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