| 张永振,周敦金,熊衍文,陈小萍,贺永文,孙强正,余滨,李娟,代永安,田俊华,草新程,金东,崔志刚,罗雪莲,李伟,卢珊,王文,彭劲松,郭文平,李明慧,李振军,张少敏,陈晨,王艳,MennoD.deJon95,徐建国.中国淮阳山地区由新蜱传布尼亚病毒引起的出血热[J].Chinese journal of Epidemiology,2011,32(3):209-220 |
| 中国淮阳山地区由新蜱传布尼亚病毒引起的出血热 |
| Hemorrhagic fever caused by a novel tick—borne Bunyavirus in Huaiyangshan，China |
| Received:September 03, 2010 |
| DOI： |
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| Author Name | Affiliation | | YongZhen Zhang | State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for DiseaBe Control and Prevention, Changping Liuzi 5, 102206, Beijing, China | | DunJin Zhou | Wuban Center for Disease Control and Pmvenfion, 430022, WuhaII’Hubei Province, China | | Yanwen Xiong | State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for DiseaBe Control and Prevention, Changping Liuzi 5, 102206, Beijing, China | | XiaoPing Chen | State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for DiseaBe Control and Prevention, Changping Liuzi 5, 102206, Beijing, China | | YongWen He | Department of Infectious Diseases, Affiliated Union Hospital of Tongji Medical CoHese, Huazhong University of Science and Technology, 430022, Wuhan, Huhni province, China | | Qiangzheng Sun | State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for DiseaBe Control and Prevention, Changping Liuzi 5, 102206, Beijing, China | | Bin Yu | Wuban Center for Disease Control and Pmvenfion, 430022, WuhaII’Hubei Province, China | | Juan Li | State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for DiseaBe Control and Prevention, Changping Liuzi 5, 102206, Beijing, China | | YongAn Dai | Department of Infectious Diseases, Zhongnan Hospital, Wuhun University, 430071, Wuhan, Hubei province, China | | JunHua Tian | Wuban Center for Disease Control and Pmvenfion, 430022, WuhaII’Hubei Province, China | | XinCheng Qin | State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for DiseaBe Control and Prevention, Changping Liuzi 5, 102206, Beijing, China | | Dong Jin | State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for DiseaBe Control and Prevention, Changping Liuzi 5, 102206, Beijing, China | | Zhigang Cui | State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for DiseaBe Control and Prevention, Changping Liuzi 5, 102206, Beijing, China | | XueLian Luo | State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for DiseaBe Control and Prevention, Changping Liuzi 5, 102206, Beijing, China | | Wei Li | Department of Infectious Diseases, Affiliated Union Hospital of Tongji Medical CoHese, Huazhong University of Science and Technology, 430022, Wuhan, Huhni province, China | | Shan Lu | State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for DiseaBe Control and Prevention, Changping Liuzi 5, 102206, Beijing, China | | Wen Wang | State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for DiseaBe Control and Prevention, Changping Liuzi 5, 102206, Beijing, China | | inSong Peng | Wuban Center for Disease Control and Pmvenfion, 430022, WuhaII’Hubei Province, China | | WenPing Guo | State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for DiseaBe Control and Prevention, Changping Liuzi 5, 102206, Beijing, China | | MingHui Li | State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for DiseaBe Control and Prevention, Changping Liuzi 5, 102206, Beijing, China | | ZhenJun Li | State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for DiseaBe Control and Prevention, Changping Liuzi 5, 102206, Beijing, China | | Shaomin Zhang | State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for DiseaBe Control and Prevention, Changping Liuzi 5, 102206, Beijing, China | | Chen Chen | State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for DiseaBe Control and Prevention, Changping Liuzi 5, 102206, Beijing, China | | Yan Wang | State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for DiseaBe Control and Prevention, Changping Liuzi 5, 102206, Beijing, China | | Menno D. de Jong | Department of Medical Microbiology, Academic Medical Center, Unirersity of Amsterdam, Amsterdam, the Netherlands | | Jianguo Xu | State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for DiseaBe Control and Prevention, Changping Liuzi 5, 102206, Beijing, China |
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| Abstract: |
| 研究背景 2009-2010年4月至7月,我国淮阳山地区农民中出现不明原因的严重出血热样病例.方法 采集疑似病例的临床标本(血液、尿液、粪便和咽拭子),在患者所在地采集蚊和蜱.从2例患者的血液样本中分离到2株病毒,并进行全基因组测序分析.采用病毒特异的RT-PCR对其他病例及节肢动物进行病毒检测,对RT-PCR阳性病例的临床和流行病学资料进行分析.结果 从2例患者的血液及从犬身上采集到的长角血蜱中分离到1种未知病毒.全基因组测序分析发现该病毒为布尼亚病毒科的一个新成员,与白蛉病毒属最接近,是其中的一个新分支.58例疑似病例中33例RT-PCR结果阳性.病例临床特征主要表现为发热、乏力、恶心、呕吐和腹泻.主要实验室结果包括白细胞及血小板减少,凝血时间异常和肝酶升高.3例患者出现出血症状,5例死亡(死亡率15%).结论 我国淮阳山地区存在着一种严重威胁生命健康的新蜱传布尼亚病毒.对于该病毒的流行病学、地理分布,以及脊椎动物宿主的生态学等需要作进一步的研究. |
| English Abstract: |
| Background:From April to July in 2009 and 2010,unexplained severe hemorrhagic fever-like illnesses occurred in farmers from the Huaiyangshan mountains range.Methods:Clinical specimens (blood,urine,feces,and throat swabs) from suspected patients were obtained and stored.Mosquitoes and ticks in affected regions were collected.Virus was isolated from 2 patients and characterized by whole genome sequencing.Virus detection in additional patients and arthropods was done by virus-specific reverse transcription (RT) PCR.Clinical and epidemiological data of RT-PCR confirmed patients were analyzed.Results:An unknown virus was isolated from blood of two patients and from Haemaphysalis ticks collected from dogs.Whole genome sequence analysis identified the virus as a novel member of the family Bunyaviridae,most closely related to the viruses of the genus Phlebovirus within which it forms a separate lineage.Subsequently,infection was confirmed by RT-PCR in 33 of 58 suspected patients.The illness in these patients was characterized by fever,severe malaise,nausea,vomiting,and diarrhea.Prominent laboratory findings included low white cell- and platelet counts,coagulation disturbances,and elevation of liver enzymes.Hemorrhagic complications were observed in 3 cases,5 (15%) patients died.Conclusions:A novel tick-borne Bunyavirus causing life-threatening hemorrhagic fever in humans has emerged in the Huaiyangshan mountain areas of China.Further studies are needed to determine the epidemiology,geographic distribution and vertebrate animal ecology of this virus. |
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