广州市绝经后妇女心血管病危险因素与骨质疏松的关系

薛文琼; 邓娟; 李静静; 刘静; 何丽萍; 陈宗遒; 陈裕明

Abstract

薛文琼,邓娟,李静静,刘静,何丽萍,陈宗遒,陈裕明.广州市绝经后妇女心血管病危险因素与骨质疏松的关系[J].Chinese journal of Epidemiology,2011,32(6):554-558

广州市绝经后妇女心血管病危险因素与骨质疏松的关系

Association between risk factors of cardiovascular diseases and osteoporosis in postmenopausal Chinese women

Received:January 21, 2011

DOI：

KeyWord: 骨质疏松心血管病危险因素横断面研究

English Key Word: Osteoporosis Cardiovascular risk factors Cross-sectional study

FundProject:中山大学"临床医学研究5010计划"(2007032);国家自然科学基金(30872100);"十一五"国家科技支撑计划(2008BAI58B02)

Author Name	Affiliation	E-mail
XUE Wen-qiong	Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China
DENG Juan	Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China
LI Jing-jing	Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China
LIU Jing	Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China
HE Li-ping	Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China
CHEN Zong-qiu	Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China
CHEN Yu-ming	Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China	chenyum@mail.sysu.edu.cn

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Abstract:

目的评估心血管病危险因素与骨质疏松的关系.方法 2008年7月至2010年1月对2202名年龄50～73岁广州市社区妇女进行问卷调查,测量血压、血脂、血糖和血尿酸,检测体脂成分、颈动脉内膜中层厚度(IMT)等心血管病危险因素,并测量桡骨和胫骨超声骨密度.采用因子分析法对危险因素提取公因子,并进行四等分位转化.结果共提取8个公因子,分别反映肥胖程度、瘦体成分、甘油三酯/尿酸、胆固醇、年龄、血压、IMT和体力活动.多因素logistic分析显示:年龄和IMT因子得分越高,瘦体成分因子得分越低,桡骨和胫骨骨质疏松的风险均越高(趋势检验:P<0 01).与最低四分位组相比,各因子得分最高组的OR值(95%C1),瘦体成分为0 62(0.44～0.88)和0.62(0.48～0.80)、年龄为4.02(2.72～5.94)和3.68(2.81～4.82)、IMT为1.41(1.00～2.00)和1.54(1.19～2.00).血压是桡骨骨质疏松的重要危险因素,肥胖是胫骨骨质疏松的独立危险因素.结论 IMT增厚、瘦体成分减少、肥胖、血压高等心血管病危险因素可显著增加骨质疏松风险,改善这些危险因素有助于预防骨质疏松.

English Abstract:

Objective To assess the relationship between cardiovascular risk factors and osteoporosis. Methods 2202 women aged 50-73 years were included in this cross-sectional study from the communities in Guangzhou, from July 2008 to January 2010. Cardiovascular risk factors including age, years since menopause, physical activity, anthropometrics, body composition, blood pressure, fasting serum lipids, glucose and uric acid, intima-media thickness(IMT) of carotid artery were assessed. Ultrasonic bone density (speed of sound) at the radius and tibia were determined. Osteoporosis was defined as T-score≤-2.5. Common factors for the cardiovascular risk factors were extracted using the factor analysis method. Results Eight common factors representing obesity, lean mass, blood triglycerides and uric acid, cholesterol, age, blood pressure, IMT and physical activity were extracted. Data from the Multivariate logistic regression showed a dose-dependent association of greater scores of age and IMT factors and lower score of lean mass factor with the increased risk of osteoporosis at the radius and tibia. As compared with the bottom quartile, the OR (95%CI) of radius and tibia osteoporosis were 0.62 (0.44-0.88) and 0.62 (0.48-0.80) for lean mass factor, 4.02 (2.72-5.94) and 3.68(2.81-4.82) for age factor, 1.41 (1.00-2.00) and 1.54 (1.19-2.00) for IMT factors, respectively. Moreover, greater blood pressure score was associated with higher risk of radius osteoporosis while the higher obese score, was correlated with the increased risk of tibia osteoporosis. Conclusion The cardiovascular-related risk factors of greater IMT, obesity, blood pressure and lower lean mass scores were associated with increased osteoporosis risks while called for more concern among the Chinese women.

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