| 刘春灵,田庚善,何耀,周平,王纯巍,王战勇,孙绍权,周艳,孙莹,孙妍,张宏伟,李莉.一起医院相关肺炎支原体感染家庭暴发的调查[J].Chinese journal of Epidemiology,2011,32(11):1110-1113 |
| 一起医院相关肺炎支原体感染家庭暴发的调查 |
| A family associated outbreak of Mycoplasma pneumoniae infection in a hospital ward |
| Received:January 11, 2011 Revised:June 18, 2012 |
| DOI： |
| KeyWord: 肺炎支原体 血清抗体 家庭 暴发 |
| English Key Word: Mycoplasma pneumoniae Serum antibodies Family Disease outbreaks |
| FundProject:安徽省教育厅自然科学基金重点资助项目(KJ2009A79)；安徽省高校优秀青年人才基金(2010SQRL070) |
| Author Name | Affiliation | E-mail | | LIU Chun-ling | Department of Infectious Disease,Air Force General Hospital of Chinese People's Liberation Army,Beijing 100142,China | liuchunling100@yahoo.com.cn | | TIAN Geng-shan | Department of Infectious Diseases and Center for Liver Diseases,Peking University First Hospital | | | HE Yao | Institute of Geriatrics, Chinese People' s Liberation Army General Hospital | | | ZHOU Ping | Department of Infectious Disease,Air Force General Hospital of Chinese People's Liberation Army,Beijing 100142,China | | | WANG Chun-wei | Department of Infectious Disease,Air Force General Hospital of Chinese People's Liberation Army,Beijing 100142,China | | | WANG Zhan-yong | Laboratory Research Center of Beijing Chaoyang Hospital,Capital Medical University | | | SUN Shao-quan | Department of Clinical Laboratory,Air Force General Hospital of Chinese People's Liberation Army | | | ZHOU Yan | Laboratory Research Center of Beijing Chaoyang Hospital,Capital Medical University | | | SUN Ying | Department of Infectious Disease,Air Force General Hospital of Chinese People's Liberation Army,Beijing 100142,China | | | SUN Yan | Beijing Deyi Clinical Laboratory | | | ZHANG Hong-wei | Department of Infectious Disease,Air Force General Hospital of Chinese People's Liberation Army,Beijing 100142,China | | | LI Li | Department of Infectious Disease,Air Force General Hospital of Chinese People's Liberation Army,Beijing 100142,China | |
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| Abstract: |
| 目的调查一起肺炎支原体(MP)感染家庭暴发的流行病学和血清学特点。方法 了解治疗陪护期间家庭成员间的接触情况；所有成员检测血清MP抗体及胸部X线检查。结果 该家庭包括3名核心成员（男童和其父、母亲）及其外祖母和叔叔（均参与照顾男童及其父住院）共5人。23 d内先后4人发病，3人X线诊断肺炎且双份血清MP抗体滴度均呈4倍以上升高。男童的父亲 和叔叔分别在发病后3d和2d检测血清MP-IgG(+)。男童及其父均有重度咳嗽。外祖母暴露于男童和叔叔暴露于父亲分别只在两家医院的空调病房内。密切接触时间最长的是男童与其母（至检测时已连续密切接触37 d），但母亲无症状，血清MP-IgM(-)。结论 既往感染获得的MP-IgG不能完全保护再次感染MP;指征病例有肺炎咳嗽重、长时间密切接触、环境通风不良和家庭成员普遍过度疲劳，几种危险因素并存可能是导致该起家庭MP感染暴发的原因。 |
| English Abstract: |
Objective To describe the epidemiological and serological features on a family associated outbreak caused by Mycoplasma pneumoniae (MP) infection occurred in Beijing in August 2007.Methods Mutual exposure of the family members was investigated and retrospective medical record was reviewed for the hospitalized patients.Serum antibodies to MP were measured and chest X-rays were taken for all the family members.Results This family consisted of 5 members,with fixed members as the boy (13 years old ),his father (43 years old) and mother (44 years old),grandmother (64 years old) and uncle (32 years old ) who was involved in taking care of the sick boy and his father.During 23 days of the event,four of all the five family members were ill.Three (boy,father and uncle) had radiographic pneumonia,whose paired sera all showed a≥fourfold increase in antibody titer,and two of them were confnrmed by chest X-ray on day 2 after onset of fever.The grandmother suffered from bronchitis,with positive(PA) serum antibody to MR Serum MP-IgG from the father and uncle was positive,3 days and 2 days after the onset of fever.The chances of contact between grandmother with the boy and uncle with the father were both only in the hospital wards.Only the mother remained asymptomatic,with her serum MP-IgM (-)and MP-IgG (+)for which the blood sample was collected 37 days after close contact with the boy.The longest time of exposure to the patients was between mother and the boy but only the mother did not increase her total workload or feeling for fatigue.
Conclusion
Results of MP-IgG from post-infection did not completely defend against therepeated MPinfection.Combined riskfactors asindex patients withsevere cough,prolonged close contact,poorly ventilation oftheenvironment,and family members withexcessive fatigue might work as the causes of this family MP outbreak. |
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