| 顾云娟，贾伟平.降糖药物与恶性肿瘤关系的研究进展[J].Chinese journal of Epidemiology,2011,32(11):1170-1173 |
| 降糖药物与恶性肿瘤关系的研究进展 |
| The relationship of antidiabetic drugs and cancer risk |
| Received:May 16, 2011 |
| DOI： |
| KeyWord: 糖尿病 恶性肿瘤 降糖药物 |
| English Key Word: Diabetes Neoplasms Antidiabetic drugs |
| FundProject:上海市科学计划委员会重大项目(09DZ1950202) |
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| Abstract: |
| 有研究认为糖尿病与某些肿瘤的发生相关。而长期的糖尿病病程中各种降糖药的使用是否也参与其中，目前还不明确 |
| English Abstract: |
| objective To analyze the risk factors related to survival time of advanced non- small cell lung cancer(NSCLC)and to establish a prediction model on survival time.Methods From 2004-2006.1 84 patients with advanced NSCLC were enrolled in the Affiliated Hospital to the Nantong Midical College.Related risk factors were analyzed.using the Buckley-James model.Both actual and predicted survival time were compared by log.rank test.Results Through Buckley-James model analysis，data showed that loS，clinical stage，treatment and pre-treatment hemoglobin were main influencing factors on survival time.Regression equation appeared to be InMONTH= 0.0108 KPS+0.0238 HB+0.4614 IIIb+0.8027Ⅲa+0.3869(radiotherapy+chemotherapy)+0.507 (radiotherapy+operation)+0.6082(chemotherapy+operation)一2.098.There was no statistical difference between the prediction and the actual models of survival time by log-rank test(P----0.575> O.05).Conclusion KPS，clinical stage，treatment and pre.treatment hemoglobin might be associated. Both the prognosis of patients with advanced NSCLC and the prediction model seemed to have practical signiflcances. |
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