| 罗芝宽,刘勇,李焕明.葛根素注射液治疗冠心病心绞痛的临床疗效和安全性研究[J].Chinese journal of Epidemiology,2012,33(6):614-616 |
| 葛根素注射液治疗冠心病心绞痛的临床疗效和安全性研究 |
| A clinical efficacy and safety study on coronary heart disease and angina treatment with Puerarin Injection |
| Received:January 06, 2012 |
| DOI： |
| KeyWord: 葛根素注射液 冠心病 心绞痛 疗效 |
| English Key Word: Puerarin Injection Coronary heart disease Angina Effect |
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| Abstract: |
| 目的 观察葛根素注射液治疗冠心病心绞痛的临床疗效和安全性.方法 选取2009年1月至2011年2月天津市第四中心医院收治的冠心病心绞痛患者388例, 随机分为治疗组和对照组各194例, 两组患者在常规治疗的基础上, 治疗组给予葛根素注射液, 对照组给予复方丹参注射液, 比较两组的临床疗效、心绞痛发作频率、心肌耗氧指数、心电图变化、血液流变学指标及不良反应.结果 治疗组的总有效率(88.14％, 171/194)明显高于对照组(61.86％, 120/194), 两组比较差异有统计学意义(P＜0.05);与对照组相比, 治疗组的心绞痛次数、心肌耗氧指数、ST段下降导联数及压低数值总和、心肌缺血时间、全血黏度低切值、红细胞电泳和红细胞压积明显降低;两组患者在治疗过程中均无明显的不良反应.结论 葛根素注射液治疗冠心病心绞痛的疗效确切且安全, 具有临床推广使用的意义. |
| English Abstract: |
| Objective To observe the clinical efficacy and safety of Puerarin Injection treatment on angina pectoris.Methods 388 patients with angina pectoris, enrolled to Tianjin Fourth Central Hospital during January 2009 and February 2011 were selected and randomly divided into treatment or control groups with 194 patients of each.Based on the conventional therapy program, one group was given Puerarin Injection as treatment group while, the other was given with Danshen Injection as control group.Clinical efficacy, the attack rate of angina pectoris, oxygen consumption, iadices on electrocardiogram, haemorheology and other adverse reactions among the two groups were compared.Results The total efficacy of the treatment group (88.14％, 171/194)was significantly higher than the control group (61.86％, 120/194) and the difference was statistically significant (P＜0.05).During the treatment, no significant adverse events were noticed in both of the two groups of patients.Conclusion The Puerarin Injection treatment program on angina pectoris seemed effective and safe. |
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