Abstract
方喜业,周冬生,崔玉军,李艳君,刘起勇,李贵昌,许磊,杨瑞馥.中国鼠疫自然疫源地分型研究Ⅳ.鼠疫耶尔森菌生物型生物学特征的探讨[J].Chinese journal of Epidemiology,2012,33(6):626-629
中国鼠疫自然疫源地分型研究Ⅳ.鼠疫耶尔森菌生物型生物学特征的探讨
Eco-geographic landscapes of natural plague foci in China Ⅳ, Characterization of biovars of Yersinia pestis, China
Received:March 29, 2012  
DOI：
KeyWord: 鼠疫耶尔森菌  生化表型  鼠疫菌生物型
English Key Word: Yersinia pestis  Biochemical phenotype  Yersinia pestis biovar
FundProject:国家科技重大专项(2008ZX10004-010)
Author NameAffiliationE-mail
FANG Xi-ye Institute of Laboratory Animal Sciences of Chinese Academy of Medical Sciences, Compared Medical Research Center of Peking Union Medical College, Beijing 100021, China xiyefang@hotmail.com 
ZHOU Dong-sheng National Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences  
CUI Yu-jun National Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences  
LI Yan-jun National Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences  
LIU Qi-yong Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Diseases Prevention and Control  
LI Gui-chang Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Diseases Prevention and Control  
XU Lei Institute of Zoology, Chinese Academy of Sciences  
YANG Rui-fu National Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences yangrf@nic.bmi.ac.cn 
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Abstract:
      鼠疫菌生物型是鼠疫菌起源进化遗传性状最稳定的生物学标准, 是鼠疫起源进化普系的“活化石”, 也是该菌起源进化最具代表性的模式.依据其对甘油和阿拉伯糖的酵解和还原硝酸盐的能力, 鼠疫菌可分为4种生物型, 即古典型(甘油酵解阳性, 阿拉伯糖酵解阳性, 硝酸盐还原阳性)、中世纪型(甘油酵解阳性, 阿拉伯糖酵解阳性, 硝酸盐还原阴性)、东方型(甘油酵解阴性, 阿拉伯糖酵解阳性, 硝酸盐还原阳性)和田鼠型(甘油酵解阳性, 阿拉伯糖酵解阴性, 硝酸盐还原阴性).前三种生物型与人类历史3次鼠疫大流行相对应, 最后一种生物型对人不致病, 但能造成田鼠鼠疫并在其自然疫源地内流行.目前中国鼠疫自然疫源地有4种鼠疫菌生物型.
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