高出生体重对儿童期血压影响的队列研究

李玉艳; 武俊青; 余金明; 戎芬; 任静朝; 高尔生; 李春英; 华芹; 卢斐杰

Abstract

李玉艳,武俊青,余金明,戎芬,任静朝,高尔生,李春英,华芹,卢斐杰.高出生体重对儿童期血压影响的队列研究[J].Chinese journal of Epidemiology,2012,33(12):1213-1217

高出生体重对儿童期血压影响的队列研究

The influence of high birth weight on the blood pressure during childhood—a cohort study

Received:June 12, 2012 Revised:June 12, 2012

DOI：10.3760/cma.j.issn.0254-6450.2012.12.003

KeyWord: 高出生体重血压队列研究

English Key Word: High birth weight Blood pressure Cohort study

FundProject:国家自然科学基金(81072364)

Author Name	Affiliation	E-mail
LI Yu-yan	School of pubic Health, Fudan University, Shanghai 200032, China Shanghai Institute of Planned Parenthood Research 3. Shanghai University of Traditional Chinese Medicine
WU Jun-qing	Shanghai Institute of Planned Parenthood Research 3. Shanghai University of Traditional Chinese Medicine	wujq16A@yahoo.com.cn
YU yin-ming	School of pubic Health, Fudan University, Shanghai 200032, China
RONG Fen	Shanghai Institute of Planned Parenthood Research 3. Shanghai University of Traditional Chinese Medicine
REN Jing-chao	School of pubic Health, Fudan University, Shanghai 200032, China Shanghai Institute of Planned Parenthood Research 3. Shanghai University of Traditional Chinese Medicine
GAO Er-sheng	上海中医药大学
LI Chun-ying	jiangyin Center of Maternal and Child health Care：
HUA qin	Huishan District Center of Maternal and Child Health Care, wuxi
LU Fei-jie	xishan Distriet Center ofMaternaf and Child Health Care,wuxi

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Abstract:

目的探讨高出生体重对儿童期血压的影响。方法对无锡市1993—1995年建立的高出生体重(暴露组)队列于2005-2007年进行随访，每个暴露对象按“出生日期±2个月”、“性别”匹配一个非暴露(正常体重儿)。共随访到1435对研究对象，对其进行问卷调查，测量身高、体重、血压。结果高出生体重组的收缩压中位数为100mmHg(Q₁一Q₃：90—110lnmHg)，舒张压为64nlnlHg(Q₁～Q₃：60一70mlTlHg)；正常体重儿组的收缩压为100inn]Hg(Q₁～Q，：90—108 rnrnHg)，舒张压为62mmHg(Q₁～Q，：60。70i/lmHg)，两组相比差异均无统计学意义。暴露组“血压升高”(高血压前期和高血压)的比例为13.66%非暴露组为11.57%(P=0.055)。调整儿童期体重指数、性别、儿童随访时年龄、母亲生育年龄、孕龄、婴儿喂养方式、儿童期是否有挑食习惯、儿童期运动时间的多因素二项式回归模型显示，高出生体重导致血压升高的RR值为1.06(0.92～1.21)，未达到统计学显著水平。结论未发现高出生体重与儿童期血压有显著关联。

English Abstract:

Objective To explore the effects of high birth weight(HBw)on blood pressure (BP)during childhood.Methods A total of 1435 couples with high or normal birth weight were selected from a birth cohort who were born between 1993 and 1995 in wuxi，China and.followed between 2005 and 2007.A questionnaire survey was conducted。with their height，weight and blood pressure measured.Results The medians of systolic blood pressure(SBP)and diastolic BP(DBP) ofHBWgroupwere 100ITlInHg(Q,-Q3：90-110i/iraHg)，64111113Hg(Q,-Q3：60—70mmHg)inthe high birth weight group，respectively，while they were 1 00 mn'l Hg(QI.Q3：90—1 08 mm Hg)，62 mill Hg(QI—Q3：60-70 nlnl Hg)in the normal weight group.No statistical significant difference was found between the exposed and unexposed groups.The proportion of elevated BP，including prehypertension and hypertension，in exposed group was 1 3.66%，a bit higher than that(11.57%)of the unexposed group(JP=0.055)。The relative risk(RR) ofHBW on elevated BP was 1.06(0。92—1.21)， after adjusted the following parameters as BMI in childhood，sex。age during the follow—up period，age of mother at delivery，gestational age，type of feeding at infancy，dietary habit as well as the frequencies of exercise during childhood.Conclusion No statistically significant correlation was found between high birth weight and blood pressure of children.

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