| 朱燕波.基于健康相关生命质量结局的“肥胖矛盾”现象[J].Chinese journal of Epidemiology,2013,34(3):294-296 |
| 基于健康相关生命质量结局的“肥胖矛盾”现象 |
| “Obesity paradox”—_a phenomenon based upon the health-related outcome on quality of life |
| Received:November 28, 2012 |
| DOI： |
| KeyWord: 肥胖矛盾 体重指数 健康相关生命质量 |
| English Key Word: Obesity paradox Body mass index Health—related quality of life |
| FundProject:国家重点基础研究发展规划“973”项目(2011CB505403) |
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| Abstract: |
| BMI的增加已被确认是许多疾病的危险因素.但有大量研究显示,相对于BMI过低和正常的多种慢性疾病患者,其超重和肥胖的临床预后反而要好,即“肥胖矛盾”现象.关于BMI与健康相关生命质量(HRQoL)关系的研究显示,体质量的增加相关于中老年、慢性病人群较高的生命质量,慢性病HRQoL的减损更重要的不是肥胖的影响而是慢性病本身.由此提出这样的启示:是否肥胖者较高的HRQoL是较高生存率的潜在机制呢? |
| English Abstract: |
| Objective To investigate the associations between polymorphisms of organic cation transporter OCTN1/2 (organic cation transporter 1/2) and the susceptibility of Crohn' s disease (CD) through a meta-analysis.Methods Databases of PubMed,EMBASE,MedLine,and CNKI (Chinese),Wanfang (Chinese) were searched for published case control studies on the association between polymorphisms of OCTN1/2 gene and the susceptibility of CD which were published before September 2012.The meta-analysis was applied with Review Manager 4.2 software and Stata 10.0 software.Results Nineteen eligible studies,including 14 from Europeans,3 from Asians,1 from Oceania,and 1 from the US were included in the meta-analysis.In total,significant associations were found between OCTN1/2 polymorphisms and the susceptibility of CD for all genetic models.In subgroup analyses,significant associations were found in the European population for OCTN1/2.Associations were not significant in the non-European population for OCTN1 (TT vs.CT:OR=1.25,95％CI:0.75-1.98,P=0.34; TT vs.CC+CT:OR=l.48,95％CI:0.95-2.29,P=0.08) and for OCTN2 (CC vs.GC:OR=1.03,95％CI:0.68-1.56,P=0.89; CC vs.GG + GC:OR=1.23,95％CI:0.83-1.82,P=0.31).However,there were significant associations found between OCTN1/2(TT vs.CC,TT+CT vs.CC,CC vs.GG,CC + GC vs.GG) polymorphisms and the susceptibility of CD found in the nonEuropean population.Conclusion Results from this meta-analysis suggested that OCTN1/2 polymorphisms were associated with the susceptibility of CD in the European population.Associations between OCTN1/2 polymorphisms and the susceptibility of CD in the non-European population required searching for large samples to confirm the findings. |
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