| 刘天俐,宋新明,陈功,郑晓瑛.精神分裂症暴力行为研究[J].Chinese journal of Epidemiology,2013,34(3):297-302 |
| 精神分裂症暴力行为研究 |
| Violent behavior in people with schizophrenia：a review |
| Received:September 27, 2012 |
| DOI： |
| KeyWord: 精神分裂症 暴力行为 |
| English Key Word: Schizophrenia Violent behavior |
| FundProject:国家重点基础研究发展规划“973”项目(2007CB5119001)；国家社科基金重大项目(09&ZD072)；长江学者奖励计划；北京大学“985”和“21l”项目(20020903)；中国博士后科学基金(20100480137) |
| Author Name | Affiliation | E-mail | | LIU Tianli | Institute of Population Research, Peking, Beijing 100871, China | | | SONG Xinming | Institute of Population Research, Peking, Beijing 100871, China | | | CHEN Gong | Institute of Population Research, Peking, Beijing 100871, China | | | ZHENG Xiaoying | Institute of Population Research, Peking, Beijing 100871, China | xzheng@pku.edu.ca |
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| Abstract: |
| 精神分裂症是最严重的精神疾病[1].其表现的暴力行为可包括对他人(躯体和性)和对物体的攻击[2].精神分裂症患者是否比正常人更易出现暴力行为曾是颇有争议的话题[3].一些国外学者认为把此类疾病与暴力犯罪相联系将对患者产生不良影响,受到不公正的社会待遇[3,4].但现在越来越多的研究证明此类疾病患者暴力行为的发生率要高于常人2～6倍[5,6].有暴力行为的精神分裂症患者其人口学特征与无精神疾病犯罪人群相似,大部分为青壮年男性,受教育程度较低,多为家庭经济贫困,并缺乏监管[7-10]. |
| English Abstract: |
| 0bjective To systematically assess the efficacy of different programs regarding the selenium supplementation formulae used for prevention and treatment of Kaschin．Beck disease (I(BD)in children．Methods PubMed，EMBASE，Cochrane Library，SCI expanded，CNKI(Chinese National Knowledge Infrastructure)，VIP(Chinese Science and Technique Journals Database)，CBM (The Chinese Biomedical Database)，Wanfang Database，CSCD(Chinese Science C：itation Database) had been electronically searched．AU the searching processes were up—dated to Dec 20 1 2 to identify randomized trials(RCTs)and non．RCTs to compare the selenium supplementation formulae wim placebo or with no intervention．Two reviewers assessed the methodological quality of the study design．including RCTs or non—RCTs according to Cochrane Handbook for Systematic Reviews of Interventions 5．1 or a checklist described by Deeks JJ．et al，respectively．Data was extracted independently．Results There were 14 RCTs and 12 non．RCTs Papers included，but showing lOW methodological quality．Data from Meta analysis showed that selenium supplementation had caused the following progresses：radiologic improvement(RR=3．28，95％CI：2．06—5．22)，higher hair selenium(SMD=2．05，95％CI：1．00—3．11)lower new radiologic lesions(OR=0．18，95％CI：0．09—0．36)than in the placebo or with no treatment groups．Both selenium and vitamin C supplementation did not show differences in radiologic improvement of metaphysis(RR=1．01，95％CI：0．84—1．22)．Combination of selenium and vitamin E supplementation showed higher radiologic improvement than the placebo group．Combination of selenium and vitamin C supplementation had no influence on the difference in radiologic improvement or hair selenium than selenium supplementation．Selenium．enriched yeast showed higher radiologic improvement than sodium selenite(70．83％vs．48．84％．P<0．05)．Selenium fertilization showed higher radiologic improvement than the non． treatment group(RR=3．98，95％C／：2．25-7．05)．Comprehensive intervention program and‘grain drying approach’also showed certain effects．C。onclusion Selenium supplementation could lead to better radiologic improvement and hair selenium．with lower new radiologic lesions．Current evidence supported its benefits on prevention and treatment of KBD．Large sample sized and well—designed trials together with the reporting on adverse outcome remained necessary． |
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