基线心率对中国北方成年人群全因死亡率的影响

陈冀; 陈朔华; 刘星; 张彩凤; 姚涛; 杨慧; 王剑利; 吴寿岭

Abstract

陈冀,陈朔华,刘星,张彩凤,姚涛,杨慧,王剑利,吴寿岭.基线心率对中国北方成年人群全因死亡率的影响[J].Chinese journal of Epidemiology,2013,34(6):622-625

基线心率对中国北方成年人群全因死亡率的影响

Relationship between baseline heart rate and all-cause death in general population

Received:January 16, 2013 Revised:June 08, 2012

DOI：

KeyWord: 心率全因死亡队列研究

English Key Word: Heart rate All-cause death Cohort study

FundProject:国家自然科学基金(30972433)；“十一五”国家科技支撑计划(2007BAcl6807)

Author Name	Affiliation	E-mail
CHEN Ji	Convalescent Home of Kailuan General Hospital,Tangshan 063000, China	drwusl@163.com
CHEN Su-hua	Kailuan General Hospital
LIU Xing	Kailuan General Hospital
ZHANG Cai-feng	Hebei United University
YAO Tao	Linxi Hospital of Kailuan General Hospital
YANG Hui	Kailuan General Hospital
WANG Jian-li	Kailuan General Hospital
WU Shou-ling	Kailuan General Hospital

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Abstract:

目的探讨基线心率水平对人群全因死亡的影响.方法选取参加2006-2007年度开滦集团健康体检有完整心电图资料且心率在40 ～ 120次/分、无心肌梗死和脑卒中病史93 716人为研究对象,研究随访期为2006年7月至2010年12月,平均随访时间(47.5±4.3)个月,随访期间每6个月收集一次全因死亡事件.结果(1)总人群心率60 ～ 69次/分组累积死亡率最低为1.61%；男性心率60～ 69次/分组累积死亡率最低为1.78%；女性心率<50次/分组中没有发生全因死亡事件,80～89次/分组累积死亡率最低为0.60%.(2)Cox风险比例模型结果显示总人群心率70～ 79次/分组、80～ 89次/分组、90 ～ 99次/分组和≥100次/分组发生全因死亡的RR值(95%CI)分别为1.187(1.039 ～ 1.336)、1.392(1.185～1.636)、1.733(1.404 ～ 2.139)和2.716(2.171～3.398),男性人群各心率组发生全因死亡的RR值(95%CI)分别为1.227(1.067 ～ 1.410)、1.481 (1.254～1.750)、1.754(1.406 ～ 2.188)、2.831(2.245～ 3.571),女性人群以心率80～ 89次/分组作为对照组,心率60～ 69次/分组、70～79次/分组和≥100次/分组发生全因死亡的RR值(95%CI)分别为0.671(0.568～ 0.793)、0.825(0.703～ 0.970)、1.925(1.512 ～2.453).结论心率≥70次/分后,随心率增加发生全因死亡事件率增加.心率与发生全因死亡的风险比呈J形曲线关系.

English Abstract:

Objective To investigate the relationship between baseline heart rate(HR) and all-cause death(ACD) in general population.Methods 93 716 workers with heart rate between 40 bpm/min-120 bpr/min and without histories of stroke were selected from the ‘2006-2007 health examination records' in Kailuan and completed the electrocardiogram exam.Related information were also gathered.These subjects were followed up from July 2006 to December 2010,with the mean time of follow-up as 47.5 ± 4.3 months.During the follow-up period,the occurrence of all-cause death was observed every half a year.Results (1) The lowest cumulative mortality rate was 1.61% in the group with 60-69 bpm/min.The lowest cumulative mortality rate was 1.78% in the group of 60-69 bpr/min in men.There was no death events observed in women with less than 50 bpm/min and the lowest cumulative mortality rate was 0.60% in the group of 80-89 bpm/min in women.(2)Data from Cox proportional hazard regression analysis showed that the RR(95%CI) of cumulative mortality rates in general population were 1.187 (1.039-1.336),1.392 (1.185-1.636),1.733 (1.404-2.139) and 2.716(2.171-3.398) in the groups of 70-79,80-89,90-99 and ≥100 bprn/min,respectively.The RRs (95% CI) of cumulative mortality in men were 1.227 (1.067-1.410),1.481 (1.254-1.750),1.754 (1.406-2.188) and 2.831 (2.245-3.571) respectively.In women,when comparing with the group of 80-89 bpm/min,the RRs (95% CI) of all-cause death were 0.671 (0.568-0.793),0.825 (0.703-0.970) and 1.925 (1.512-2.453) respectively in the groups of 60-69,70-79 and ≥ 100 bpm/min.Conclusion When HR exceeding ≥70 bpm/min,the increase of HR would also increase the rate of ACD.Results of our study also showed a J-shaped curve relation between HR and mortality.

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