重庆市O～5岁儿童出生缺陷空间地理分布 及其与土壤化学元素关系的研究

董燕; 钟朝晖; 李红; 李杰; 王应雄; 彭斌; 张茂忠; 黄巧; 闫菊; 徐飞龙

Abstract

董燕,钟朝晖,李红,李杰,王应雄,彭斌,张茂忠,黄巧,闫菊,徐飞龙.重庆市O～5岁儿童出生缺陷空间地理分布及其与土壤化学元素关系的研究[J].Chinese journal of Epidemiology,2013,34(10):975-979

重庆市O～5岁儿童出生缺陷空间地理分布及其与土壤化学元素关系的研究

Spatial distribution of birth defects among children aged 0 to 5 years and its relationship with soil chemical elements in Chongqing

Received:June 12, 2013

DOI：10．3760/cma．j．issn．0254—6450．2013．10．008

KeyWord: 出生缺陷|土壤|化学元素|地理信息系统|空间分布

English Key Word: Birth defect|Soil|,Chemical elements|Geographic information system|Spatial distribution

FundProject:重庆市科技攻关计划(201199c503)；重庆市人口和计划生育科学技术研究院资助项目(渝人计研发[2010122号)

Author Name	Affiliation	E-mail
DONG Yan	Department of idemiology, School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China
ZHONG Zhao-hui	Department of idemiology, School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China	zzhlxb@qq.com
LI Hong	Institute ofScience and Technologyfor Population and Family Planning
LI Jie	Institute ofScience and Technologyfor Population and Family Planning
WANG Ying-xiong	Faculty of Basic Medical Sciences
PENG Bin	Department ofStatistics, School of Public Health and Management, Chongqing Medical University
ZHANG Mao-zhong	Bureau ofGedogical Prospecting, Geological Brigade in Southeast ofSichuan
HUANG Qiao	Department of idemiology, School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China
YAN Ju	Department of idemiology, School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China
XI Fei-long	Department ofStatistics, School of Public Health and Management, Chongqing Medical University

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Abstract:

目的探讨出生缺陷发生率与土壤化学元素含量的相关性，为筛选致病因子及其防治提供科学依据。方法用Maplnfo 7．0软件绘制33个研究区出生缺陷发生率和11种土壤化学元素含量水平的空间分布地图，将两变量地图叠加进行空间相关性分析；采用SAS 8．0软件做两者的单因子、多因子及主成分分析，并综合评价两者的关联程度。结果出生缺陷发生率空间分布图与土壤化学元素铜(Cu)、铬(Cr)、碘(I)、硒(Se)、锌(zn)含量异常的分布图呈一定程度的负相关，与铅(Pb)含量水平呈一定程度正相关；主成分回归方程提示：Cu(0．002)、砷(As)(一0．07)、镉 (Cd)(o．05)、Cr(一0．001)、Zn(0．001)、I(一0．03)、Pb(O．08)、氟(F)(一o．002)元素含量的高低可能是影响出生缺陷患病率的重要因素。结论出生缺陷发生率与土壤中Cu、Cr、I、Se、zn、Pb的含量水平在空间地理分布上具有相关性，其中元素Cr、I、Pb可能是出生缺陷发生的原因之一。

English Abstract:

Objective To explore the correlation between the incidence of birth defects and the contents of soil elements SO as to provide a scientific basis for screening the related pathogenic factors that inducing birth defects for the development of related preventive and conlTol strategies． Methads Maplnfo 7．0 software was used to draw the maDs on spatial distribution regarding the incidence rates of birth defects and the contents of 1l chemical elements in soilin the 33 studied areas． Variables on the two maDs were superposed for analyzing the spatial correlation．SAS 8．0 software was used to analyze single factor．multi．factors and principal components as well as to comprehensively evaluate the degrees of relevance．Results Different incidence rates of birth defects showed in the maps of spatial distribution presented certain degrees of negative correlation with anomalies of soil chemical elements，including copper，chrome，iodine，selenium，zinc while positively correlated with the 1evels of lcad．Results from the principal component regression equation indicating thatthe contents ofcopper(0．002)，arsenic(-0．07)，cadmium(0．05)，chrome(-0．001)，zinc(0．001)，iodine(-0．03)，lead(0．08)，fluorine(-0．002)might serve as important factors that related to the prevalence of birth defects．Conclusion Through the study on spatial distribution，we noticed that the incidence rates of birth defes were related to the contents of copper，chrome，iodine， selenium．zinc，lead in soil while the contents of chrome，iodine and lcad might lcad to the occurrence ofbirth defects．

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