体重指数与谷氨酰半胱氨酸合成酶催化亚基基因多态性的交互作用对女性乳腺癌风险的影响

林威; 唐录英; 岑玉玲; 林颖; 苏逢锡; 贾卫华; 任泽舫

Abstract

林威,唐录英,岑玉玲,林颖,苏逢锡,贾卫华,任泽舫.体重指数与谷氨酰半胱氨酸合成酶催化亚基基因多态性的交互作用对女性乳腺癌风险的影响[J].Chinese journal of Epidemiology,2013,34(11):1115-1119

体重指数与谷氨酰半胱氨酸合成酶催化亚基基因多态性的交互作用对女性乳腺癌风险的影响

Interaction of body mass index and a polymorphism in gene of catalytic subunit of glutamatecysteineligase on breast cancer risk among Chinese women

Received:June 25, 2013

DOI：10.3760/cma.j.issn.0254-6450.2013.011.016

KeyWord: 乳腺癌体重指数谷氨酰半胱氨酸合成酶催化亚基

English Key Word: Breast cancer Body mass index Catalytic subunit of glutamate—cysteine ligase

FundProject:国家自然科学基金(81072383)

Author Name	Affiliation	E-mail
LlN Wei	The School of Public Health
TANG Lu-ying	TheThird Affliated Hospital
CEN Yu-ling	The School of Public Health
LIN Ying	The First Affiliated Hospital
SU Feng-xi	The Second Affliated Hospital
JIA Wei-hua	CancerCenter, Sun Yat-sen University, Guangzhou 510080, China
REN Ze-fang	The School of Public Health	renzef@mail.sysu.edu.cn

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Abstract:

目的探讨谷氨酰半胱氨酸合成酶催化亚基(GCLC)rsl7883901多态性位点对BMI与乳腺癌关联的影响。方法于2008年10月至2010年6月对中山大学3所附属医院新诊断的839例乳腺癌患者(病例组)在接受治疗前及同时期863名年龄频数匹配的对照(对照组)进行问卷调查和收集血样；采用基质辅助激光解吸一飞行时间质谱仪(MALDI—TOF.MS)，在Sequenom平台检测rsl7883901位点基因型；采用非条件logistic回归分析计算BMI和GCLC与乳腺癌关联的OR值及其95%CI。结果(1)病例组和对照组接受调查时当前的BMI、20岁时的BMI和GCLCrsl7883901位点分布的差异均无统计学意义(P=0.44、0.52和0.47)；(2)未发现当前的BMI与绝经前及绝经后乳腺癌风险相关，20岁时BMI为18.5。22.9 kg/m²可降低绝经前乳腺癌风险(OR=0.69，95%CI：0.48~1.00)，而未发现其与绝经后乳腺癌风险相关；(3)在GCLC rsl7883901位点突变型CT/TT人群中，当前的BMI>/25 kg/m2显著增加乳腺癌风险(OR=1.91，95%CI：1.09～3.36)，而20岁时BMI为18.5～22.9 kg/m²与降低乳腺癌风险有关(OR=O.56，95%CI：0.31～o.99)。当前的BMI与GCLC基因多态性对乳腺癌发生风险存在交互作用(P=0.043)，而20岁时的BMI与GCLC交互项无统计学意义(P=0.15)。结论20岁时增加BMI可能是绝经前乳腺癌的保护因素；GCLC rsl7883901位点本身与乳腺癌发生风险无显著关联，但其变异基因型可使当前的肥胖状态(BMI≥25 kg/m2)显著增加乳腺癌发生风险。

English Abstract:

0bjective To investigate the interaction of body mass index(BMI)and a singlenucleotide polymorphism(SNP.rsl7883901)in catalytic subunit of glutamate-cysteine ligase(GCLC)on breast cancer risk.Methods A total of 839 women with incident breast cancer and 863age.matched controls without cancer were recruited at the same period in three affiliated hospitals ofSun Yat.sen University in Guangzhou from 0ctober 2008 to June 2010.GCLC rsl7883901 wasgenotyped by MALDI-TOF-MS.Binary unconditional logistic regression was applied to calculateodds ratios and 95%confidence intervals.Results The difference of present BMI and BMI at age 20was not statistically significant between cases and controls,either as the genotypes of GCLC.Noassociation was found between BMI at present and premenopausal or postmenopausal breast cancerrisk.But we found that women who had a BMI at age 20 of 1 8.5 to 22.9 had a marginally decreasedrisk ofpremenopausal breast cancer OR and 95％CI：0.69(0.48,1.00)I.Among women with CT/TTgenotypes,whose present BMl was greater than 25 had a increased risk[OR and 95%CI：1.9 1(1.09,3.36)] ofbreast cancer and a decreased risk 0R and 95%CI：0.56(0.31,0.99)f with a BMI at age20 of 1 8.5 t0 22.9.There was a interaction between GCLC gene(rs 1788390 1)and BMI at oresentin breast cancer risk(P=0.043),which was not found between rsl788390l and BMI at age 20.Conclusion Our findings indicate BMI at age 20 may be a protective factor of premenopausal breastcancer,while no association appears between GCLC(rsl7883901)and breast cancel Obesity atpresent may significantly increase the risk of breast cancer among women with CT/TT genotypes ofGCLC(rsl7883901).

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