深圳市常住人口乙型肝炎血清流行病学调查

程锦泉; 马汉武; 谢旭; 路滟; 张艳彪; 董书贤; 王廷哲; 刘益民; 凌文华; 郝元涛

Abstract

程锦泉,马汉武,谢旭,路滟,张艳彪,董书贤,王廷哲,刘益民,凌文华,郝元涛.深圳市常住人口乙型肝炎血清流行病学调查[J].Chinese journal of Epidemiology,2013,34(12):1179-1182

深圳市常住人口乙型肝炎血清流行病学调查

Sero-epidemiological investigation on hepatitis B among permanent residents in Shenzhen area

Received:July 12, 2013

DOI：10.3760/cmaj.issn.0254-6450.2013.012.006

KeyWord: 乙型肝炎流行病学

English Key Word: Hepatitis B Epidemiology

FundProject:国家“十一五”科技重大专项 (2009ZXl0001—018)

Author Name	Affiliation	E-mail
Cheng Jinquan	Center for Disease Control and Prevention, Shenzhen 518055. China	cjinquan@szcdc.net
Ma Hanwu	Center for Disease Control and Prevention, Shenzhen 518055. China
Xie Xu	Center for Disease Control and Prevention, Shenzhen 518055. China
Lu Yan	Center for Disease Control and Prevention, Shenzhen 518055. China
Zhang Yanbiao	Center for Disease Control and Prevention, Shenzhen 518055. China
Dong Shuxian	and Population-Family, Planning Bureau of Luohu
Wang Tingzhe	and Population-Family, Planning Bureau of Luohu
Liu Yimin	Baoan Center for Disease Control and Preventionn, Shenzhen
Ling Wenhua	College of Public Health,Zhongshan University
Hao Yuantao	College of Public Health,Zhongshan University

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Abstract:

目的调查深圳市常住人13 HBV感染情况及流行特征。方法2010年采用多阶段分层随机抽样方法对深圳市罗湖区和宝安区1～59岁常住居民进行问卷调查,并采集静脉血,用ELISA检测乙型肝炎(乙肝)病毒表面抗原(HBsAg)和乙肝病毒表面抗体(抗-HBs)。结果3771人中,HBsAg阳性252例,标化阳性率为9.73%；抗一HBs阳性2712例,标化阳性率为72.83%。HBsAg阳性率随年龄增长呈升高趋势(P<0.05)；深圳市户籍与非深圳市户籍居民HBsAg阳性率差异无统计学意义(P>0.05),但深圳市户籍人口抗一HBs阳性率(78.32%)高于非深圳市户籍人群(66.03%),差异有统计学意义(X²=41.613,P<0.001)；HBsAg阳性率在不同职业人群中差异较大,其中农民最高,达24.13%,抗-HBs阳性率中医护人员最高(89.10%)；初中文化程度人群HBsAg阳性率最高(12.76%),大专及以上文化程度人群抗-HBs阳性率最高,平均为81.00%,而初中水平人群抗-HBs阳性率最低,仅为62.45%；出生地为广东、深圳地区的调查人群HBsAg阳性率均超过10%,抗一HBs阳性率以深圳和广东地区出生人群最高,分别为74。48%和76.47%。结论深圳市乙肝感染低于广东省,但高于全国平均水平。

English Abstract:

0bjective To understand the infection status and epidemiological features ofHBV in permanent residents of Shenzhen city.Methods A multi.stage stratified random samplingmethod was performed for questionnaire survey to permanently.registered residents of 1-59 years oldin Luohu and Baoan district of Shenzhen in 20 1 0，and blood samples of the subjects were collected.Hepatitis B virus-related surface antigen(I-IBsAg)and hepatitis B virus surface antibody(anti-HBs)were detected with ELISA.ResultsP>0.05).The prevalence of HBsAg was reduced with increasingage.The differences of the prevalence of HBsAg between Shenzhen permanent registered andnon-permanent registered population were not significant，but the prevalence of anti-HBs inPermanent registered residents(78.32%)was higherthan in non permanent(66.03%.X²=41.613.P<0.001).The prevalence of HBsAg was significantly different in various occupational and educational1evels.Peasants had me highest prevalence(24.13%)and medical workers had the highestprevalence of anti·HBs(89.10%).People with juniorhigh school education had the high estprevalence of HBsAg(12.76%)and the lowest of anti.HBS(62.45%).Population with high.1eveleducation had the highest prevalence of anti.HBs(8 1.00%average).The prevalence of HBsAg wasover 10%in people who were bom in Shenzhen and Guangdong province.and the anti.HBs was thehighest in Shenzhen population with the prevalence as 74.48%and 76.47%，respectively.Conclusion In the Shenzhen resident population.the overall prevalence of HBV was lower than theaverage level of Guangdong province.but higher than the national wide.

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