| 尚晓瑞,宋洁云,刘芳宏,马军,王海俊.葡萄糖激酶调节蛋白基因rs780094 多态性与儿童青少年血脂关系的研究[J].Chinese journal of Epidemiology,2014,35(6):626-629 |
| 葡萄糖激酶调节蛋白基因rs780094 多态性与儿童青少年血脂关系的研究 |
| Association between rs780094 polymorphism in GCKR and plasma lipid levels in children and adolescents |
| Received:December 13, 2013 |
| DOI： |
| KeyWord: 血脂 葡萄糖激酶调节蛋白 基因多态性 儿童 |
| English Key Word: Plasma lipid Glucokinase regulatory protein Gene polymorphism Child |
| FundProject:国家自然科学基金（81172683）;国家重点基础研究发展计划（973）项目（2012CB517501） |
| Author Name | Affiliation | E-mail | | Shang Xiaorui | Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China | | | Song Jieyun | Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China | | | Liu Fanghong | Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China | | | Ma Jun | Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China | majunt@bjmu.edu.cn | | Wang Haijun | Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China | whjun1@bjmu.edu.cn |
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| Abstract: |
| 目的 探讨葡萄糖激酶调节蛋白（GCKR）基因rs780094 的多态性与儿童青少年血脂水平的关系。方法 选取1 026 名7～18 岁中小学生为研究对象。由专职人员记录学生一般情况和既往病史，检测身高、体重，并采集清晨空腹肘静脉血，测定血清TC、TG、HDL-C和LDL-C水平。利用基质支持的激光释放/电离飞行时间质谱分析（MALDI-TOF MS）进行GCKR 基因rs780094 位点的基因型检测。采用多元线性回归和多元logistic 回归分析基因多态性与血脂水平的关系。结果 调整年龄、年龄的平方和性别，GCKR基因rs780094 多态性A等位基因与TC、TG和LDL-C 的水平增加存在相关性（b＝0.06 mmol/L，P＝0.037;b＝0.09 mmol/L，P＜0.001;b＝0.05 mmol/L，P＝0.040）;rs780094 多态性与TG、LDL-C 异常也存在相关性（OR＝1.60，95%CI：1.30～1.97，P＜0.001;OR＝1.35，95%CI：1.02～1.80，P＝0.036）。结论 GCKR 基因rs780094 位点的多态性与儿童青少年血脂水平有关，A等位基因可能是血脂增高的遗传因素。 |
| English Abstract: |
| Objective To investigate the association between rs780094 polymorphism in glucokinase regulatory protein（GCKR） and plasma lipid levels in children and adolescents. Methods 1 026 Chinese children aged 7 to 18 years were recruited，with anthropometric measurements，detection of plasma lipid levels and genotyping of rs780094 performed. Relationships between polymorphism and plasma lipid levels were tested，using multivariate linear regression and logistic regression. Results A-allele of rs780094 in GCKR was associated with increased TC，TG and LDL-C levels（b＝0.06 mmol/L，P＝0.037;b＝0.09 mmol/L，P＜0.001;b＝0.05 mmol/L，P＝0.040） under the additive model adjusted for age，age square and gender. The rs780094 in GCKR was also associated with abnormal levels of TG and LDL-C（OR＝1.60，95% CI：1.30-1.97，P＜0.001;OR＝ 1.35，95%CI：1.02-1.80，P＝0.036）. Conclusion The rs780094 in GCKR was associated with plasma lipid levels in children and adolescents while A-allele of rs780094 might serve as genetic factor for the increased plasma lipid levels. |
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