| 冯录召,赖圣杰,李夫,叶先飞,李飒,任翔,张洪龙,李中杰,余宏杰,杨维中.2009－2012 年我国6 省（市）5 岁以下儿童住院肺炎病例的病毒病原学分析[J].Chinese journal of Epidemiology,2014,35(6):646-649 |
| 2009－2012 年我国6 省（市）5 岁以下儿童住院肺炎病例的病毒病原学分析 |
| Viral etiologies of hospitalized pneumonia patients aged less than five years in six provinces， 2009-2012 |
| Received:April 02, 2014 |
| DOI： |
| KeyWord: 呼吸道合胞病毒 肺炎 婴幼儿 |
| English Key Word: Respiratory syncytial virus Pneumonia Young children |
| FundProject:国家科技重大专项（2009ZX10004-201，2012ZX10004-201） |
| Author Name | Affiliation | | Feng Luzhao | Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | Lai Shengjie | Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | Li Fu | Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | Ye Xianfei | Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | Li Sa | Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | Ren Xiang | Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | Zhang Honglong | Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | Li Zhongjie | Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | Yu Hongjie | Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | Yang Weizhong | Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China |
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| Abstract: |
| 目的 分析2009－2012 年6 个省（直辖市）＜5 岁儿童住院肺炎病例的病毒性病原，并描述其季节性分布。方法 从北京、上海、重庆、广东、甘肃、四川6 个省（直辖市）选取开展全国发热呼吸道症候群监测的8 家医院，对其纳入的＜5 岁儿童住院肺炎病例的人口统计学信息、临床症状和体征以及流感病毒、副流感病毒、呼吸道合胞病毒（RSV）、冠状病毒、偏肺病毒、博卡病毒、腺病毒的实验室检测结果，分不同年份、年龄组对儿童住院肺炎病例的病原谱进行分析，并描述各种病原阳性病例的季节性分布特征。结果 2009－2012 年，8 家监测医院共纳入＜5 岁儿童住院肺炎病例4 508 例，其中至少1 种病毒检测阳性的2 688 例（阳性率59.6%）。RSV 阳性率最高（21.3%），其次为副流感病毒（7.1%）和流感病毒（5.2%），博卡病毒、腺病毒和偏肺病毒阳性率分别为3.8%、3.6%和2.6%，冠状病毒最低（1.1%）。RSV、流感病毒、副流感病毒、博卡病毒和偏肺病毒的季节性明显。结论 RSV是我国＜5 岁儿童住院肺炎病例的最常见病毒性病原，应在流行高峰季节采取预防控制措施以降低其对婴幼儿健康的严重危害。 |
| English Abstract: |
| Objective To analyze the viral etiologies of hospitalized pneumonia patients aged less than five years in six provinces during 2009-2012，and to describe the seasonality of the detected viral etiologies. Methods Eight hospitals were selected in six provinces from a national acute respiratory infection surveillance network. Demographic information，clinical history and physical examination，and laboratory testing results of the enrolled hospitalized patients aged less than five years with pneumonia，including respiratory syncytial virus （RSV），human influenza virus， adenoviruses（ADV），human parainfluenza virus（PIV），human metapneumovirus（hMPV），human coronavirus（hCoV）and human bocavirus（hBoV）were analyzed. The viral etiology spectrum of the enrolled patients was analyzed by age-group，year，and seasonality of the detected viral etiologies were described. Results 4 508 hospitalized children less than five years old，with pneumonia from 8 hospitals were included，and 2 688（59.6%）patients were positive for at least one viral etiology. The most frequent detected virus was RSV（21.3%），followed by PIV（7.1%）and influenza（5.2%），hBoV （3.8%），ADV（3.6%）and hMPV（2.6%）. The lowest positive rates in hCoV（1.1%）. RSV，influenza， PIV，hBoV and hMPV all showed the nature of seasonality. Conclusion RSV was a most common viral etiology in the hospitalized young children less than 5 years of age with pneumonia. Prevention measures should be conducted to decrease its severe impact to the young infants and children in China. |
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