| 杨天敢,黎宏章,陈娇娥,曾万里,毛珺梁,张志华,杨军华,杨宁敏,屠苗颖,张建中.浙江省台州地区2010－2013 年幽门螺杆菌常用抗生素耐药监测[J].Chinese journal of Epidemiology,2014,35(6):704-707 |
| 浙江省台州地区2010－2013 年幽门螺杆菌常用抗生素耐药监测 |
| Epidemiological study on antibiotic resistance among Helicobacter pylori in Taizhou district， Zhejiang，2010-2013 |
| Received:May 12, 2014 |
| DOI： |
| KeyWord: 幽门螺杆菌 抗生素 耐药 |
| English Key Word: Helicobacter pylori Antibiotic Drug resistance |
| FundProject:国家“十二五”科技支撑计划（2012BAI06B02）;浙江省公益技术研究社会发展项目（2010C33035）;浙江省医药卫生科技计划项目（2012KYB248）;浙江省医学会临床科研基金（2013ZYC-A145） |
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| Abstract: |
| 目的 了解浙江省台州地区幽门螺杆菌（HP）对常用抗生素的耐药谱。方法 收集2010 年1 月至2013 年12 月台州市4 家医院住院及门诊39 099 例胃镜检查患者的胃黏膜标本，进行HP分离培养;采用平板掺入法检测分离株对甲硝唑、克拉霉素、阿莫西林、庆大霉素、左氧氟沙星和呋喃唑酮的耐药性。结果 共获得HP临床分离株13 038 株，耐药检测显示，HP对甲硝唑的耐药率＞93%，对阿莫西林、庆大霉素和呋喃唑酮的耐药率＜0.5%。对左氧氟沙星和克拉霉素的耐药率较高，于2011 年达到高点，此后耐药率逐年降低（P＜0.01）;左氧氟沙星和克拉霉素的联合耐药率在2011 年达到最高（P＜0.01），此后明显下降，但2013 年与2012 年相比，差异无统计学意义（P＞0.05）。结论 台州地区HP分离株对甲硝唑的耐药率最高，对阿莫西林、庆大霉素和呋喃唑酮耐药率较低，临床治疗应选用阿莫西林、庆大霉素和呋喃唑酮。左氧氟沙星和克拉霉素耐药率有下降趋势，但两药的联合耐药率未出现降低，多耐菌株的出现及其原因应引起重视。 |
| English Abstract: |
| Objective To study the infection status of Helicobacter pylori （H. pylori） and sensitivity to commonly used antibiotics in Taizhou district，Zhejiang province. Methods 39 099 cases aged between 5 and 95 years old（mean as 48.42 years）were involved during January 2010 to December，2013 for this study. Sex ratio was 1 ∶ 0.95. Yearly distribution of the number of cases were 5 031，6 709，11 902 and 15 457 in 2010，2011，2012 and 2013，respectively. Gastric mucosal specimens were collected and H. pylori strains were isolated and cultured in the same platform in Zhiyuan Medical Inspection Institute of Hangzhou. Resistance tests of all the H. pylori isolates were performed to 6 commonly used antibiotics：metronidazole，clarithromycin，amoxicillin，gentamicin， levofloxacin and furazolidone with the agar dilution method. The antibiotic resistance rates of H. pylori strains isolated during year 2010-2013 and the changing trends were analyzed. Results Resistance rates to levofloxacin and clarithromycin kept at higher level and the highest was in 2011 and then decreased in both 2012 and 2013 （P＜0.01）. The resistance rates to both levofloxacin and clarithromycin reached the highest in 2011（P＜0.01），and decreased thereafter，with no significant change in 2013 to 2012（P＞0.05）. Conclusion Antibiotic resistance rate against metronidazole for HP isolate was highest. Resistance rate against amoxicillin and furazolidone，gentamicin was low. Clinical treatment should choose amoxicillin and furazolidone，gentamicin. The resistance rates to levofloxacin and clarithromycin had been seen at a significantly downwarding trend since 2011. However，the combined resistance rates to levofloxacin and clarithromycin did not seem to reduce since 2012. |
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