| 苏迎盈,刘慧鑫,吴静,朱琳,汪宁.中国HIV-1基因亚型分布及流行趋势[J].Chinese journal of Epidemiology,2014,35(10):1164-1168 |
| 中国HIV-1基因亚型分布及流行趋势 |
| Distribution of HIV-1 genotypes in China：a systematic review |
| Received:April 09, 2014 |
| DOI：10.3760/cma.j.issn.0254-6450.2014.10.020 |
| KeyWord: 人类免疫缺陷病毒-1 基因型 系统综述 |
| English Key Word: HIV-1 Genotype Systematic review |
| FundProject:国家“十二五”科技重大专项（2012ZX10001-001） |
| Author Name | Affiliation | E-mail | | Su Yingying | National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | Liu Huixin | National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | Wu Jing | National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | Zhu Lin | National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | Wang Ning | National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | wangnbj@163.com |
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| Abstract: |
| 目的 分析我国HIV-1 基因型的分布及变化趋势。方法 计算机检索中国医院知识总库（CHKD，1994-）、万方数据资源系统（1998-）、中国生物医学文献数据库（CBMDisc）以及PubMed数据库，并结合文献追溯的方法，收集我国HIV-1 基因分型的相关文献，提取符合标准的文献信息，对相同的HIV-1 亚型分别按地区、研究时间、研究人群分组，并进行数量合并，计算百分比。结果 共纳入175 篇文献，包含285 条记录。我国HIV-1 流行最广泛的毒株为CRF01_AE、CRF07_BC重组型，以及B’亚型，但不同地区基因亚型存在差异。北方地区流行毒株比较单一，且流行较稳定。南方地区HIV-1 毒株的亚型分布较为复杂，存在多种亚型及流行重组型，同时存在一定比例新的独特重组亚型流行。我国早期HIV-1 以B’及C亚型流行为主，近年来，尤其是2007 年以后，CRF01_AE重组型逐渐增高，成为我国优势毒株，同时存在一定比例的CRF07_BC、CRF08_BC重组型和B’亚型流行。结论 我国HIV-1 基因型地区分布、人群分布差异较大，且随着时间的推移，基因型分布产生较大的变化，流行更为复杂。 |
| English Abstract: |
| Objective To provide information on the geographical distribution of HIV-1 genotypes and subtypes in the population of China. Methods A comprehensive search was carried out in China Hospital Knowledge Database（CHKD）,Wanfang（Chinese）,CBMDisc and PubMed databases to identify all studies published related to HIV-1 genotypes in China. All studies were grouped according to the sites,period and objects for analyzing the distribution of HIV genotypes.Results A total of 175 studies were included in this Meta-analysis,which contained 285 records. We found that the predominate genotypes in China were B'subtype,CRF01_AE,CRF07_BC and CRF08_BC,but the subtype distribution of HIV-1 was different in the western and southern parts of the country. CRF01_AE had a significant increase while subtype B'showed a decrease. There were various HIV-1 subtypes among individuals who acquired HIV through sexual contacts and CRF01_AE was most commonly identified in this group of people. Conclusion The distribution of HIV-1 genotypes in Chinese people significantly changed,together with high complexity of the HIV-1 epidemics noticed in China. |
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