云南省开远市美沙酮门诊在治者HIV、HCV感染现状分析

普丽芳; 苏迎盈; 王桂香; 白俊

Abstract

普丽芳,苏迎盈,王桂香,白俊.云南省开远市美沙酮门诊在治者HIV、HCV感染现状分析[J].Chinese journal of Epidemiology,2015,36(8):829-831

云南省开远市美沙酮门诊在治者HIV、HCV感染现状分析

Prevalence of HIV and HCV infections in patients receiving methadone maintenance treatment in Kaiyuan, Yunnan

Received:December 25, 2014

DOI：10.3760/cma.j.issn.0254-6450.2015.08.013

KeyWord: 美沙酮门诊艾滋病病毒丙型肝炎病毒感染

English Key Word: Methadone maintenance treatment HIV HCV Infection

FundProject:

Author Name	Affiliation	E-mail
Pu Lifang	Kaiyuan Center for Disease Control and Prevention, Kaiyuan 661699, China
Su Yingying	National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention	syytthl1987@163.com
Wang Guixiang	Kaiyuan Center for Disease Control and Prevention, Kaiyuan 661699, China
Bai Jun	Kaiyuan Center for Disease Control and Prevention, Kaiyuan 661699, China

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Abstract:

目的了解开远市美沙酮维持治疗(MMT)在治者HIV/HCV感染率及其危险因素。方法以2014年6月MMT在治者为研究对象, 获得HIV/HCV感染率, 采用logistic回归模型分析相关危险因素。结果 2014年6月, 开远市MMT在治人数为275人, 美沙酮平均治疗时间为(4.0±2.4)年, 入组时HIV阳性者142人, 感染率为51.6%, 美沙酮治疗期间未发现HIV新发感染。入组时HCV阳性者222人, 感染率为80.7%, 美沙酮治疗期间共发现17例HCV新发感染, 新发感染率为32.1%(17/56);HIV/HCV混合感染135人, 混合感染率为49.1%。多因素logistic回归分析发现: 未婚/离异/丧偶(调整OR=2.39, 95%CI: 1.29~4.43)、有注射毒品史(调整OR=5.52, 95%CI: 2.69~11.35)、有共用注射器史(调整OR=2.32, 95%CI: 1.04~5.18)及吸毒时间长的MMT者感染HIV的风险更高;对于HCV感染, 注射吸毒史为其独立危险因素(调整OR=11.54, 95%CI: 4.79~27.80)。结论开远市MMT在治者的HIV、HCV、HIV/HCV混合感染率均高于云南省其他地区。应加强注射吸毒人群中清洁针具交换及HIV/HCV干预工作。

English Abstract:

Objective To investigate the risk factors for HIV and HCV infections in patients receiving methadone maintenance treatment(MMT) in Kaiyuan, Yunnan province. Methods Patients receiving MMT in June 2014 in Kaiyuan were included in this study. The prevalence of HIV and HCV infections were calculated and logistics regression analysis was conducted to identify related risk factors. Results In June 2014, 275 patients received MMT, their average duration of MMT was 4.0±2.4 years. The overall HIV infection rate was 51.6%(142/275). All the HIV infection occurred before MMT. In 275 patients, 222 were infected with HCV before MMT, and 17 new HCV infections occurred during MMT. And the HIV/HCV co-infection rate was 49.1%. The results from multivariate logistic regression analysis indicated that the risk of HIV infection was higher in those who were unmarried/divorced/widowed (adjust OR=2.39, 95%CI: 1.29-4.43) and injecting drug users (adjust OR=5.52, 95%CI: 2.69-11.35), sharing needles with others (adjust OR=2.32, 95%CI: 1.04-5.18) and had longer history of drug use. For HCV infection, injecting drug use was the independence risk factor(adjust OR=11.54, 95%CI: 4.79-27.80). Conclusion The prevalence of HIV, HCV infections and HIV/HCV co-infection in patients in MMT clinic were higher in Kaiyuan than in other areas in Yunnan. More intervention should be given to the patients who had history of injecting drug use.

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