甘肃省武威市城市与农村不同人群碘营养及甲状腺功能对比研究

王燕玲; 窦瑜贵; 朱小南; 郑菁

Abstract

王燕玲,窦瑜贵,朱小南,郑菁.甘肃省武威市城市与农村不同人群碘营养及甲状腺功能对比研究[J].Chinese journal of Epidemiology,2015,36(10):1095-1098

甘肃省武威市城市与农村不同人群碘营养及甲状腺功能对比研究

A comparative study on iodine nutrition and thyroid function of different population in urban and rural areas of Wuwei,Gansu province

Received:March 03, 2015

DOI：10.3760/cma.j.issn.0254-6450.2015.10.013

KeyWord: 碘甲状腺

English Key Word: Iodine Thyroid gland

FundProject:国家科技支撑计划(2006BAI06B05);甘肃省卫生行业科研计划管理项目(GWGL2011-3,GWGL2013-58)

Author Name	Affiliation	E-mail
Wang Yanling	Gansu Provincial Center for Disease Control and Prevention, Lanzhou 730020, China	wylxiao@126.com
Dou Yugui	Gansu Provincial Center for Disease Control and Prevention, Lanzhou 730020, China
Zhu Xiaonan	Gansu Provincial Center for Disease Control and Prevention, Lanzhou 730020, China
Zheng Jing	Gansu Provincial Center for Disease Control and Prevention, Lanzhou 730020, China

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Abstract:

目的分析甘肃省武威市城市和农村不同人群碘营养水平及甲状腺功能。方法于2009年4月至2010年1月采用横断面调查方法抽取甘肃省武威市城市和农村8~10岁儿童、18~45岁成年人(不包括哺乳期妇女及孕妇)、哺乳期妇女及孕妇进行调查,采集样本人群一次随机尿样及空腹血样。砷铈催化分光光度法检测尿碘;化学发光免疫法检测血清促甲状腺激素(TSH)、游离甲状腺激素(FT₄)、游离三碘腺原氨酸(FT₃);放射免疫法检测血清甲状腺球蛋白抗体(TGAb)、甲状腺微粒体抗体(TMAb)。尿碘、TSH组间比较采用非参数检验,FT₄、FT₃组间比较采用t检验,率的比较用χ²检验。结果甘肃省武威市城市和农村儿童、成年人、孕妇和哺乳期妇女的尿碘M(μg/L)分别为358.6、189.0、255.4、239.5和387.6、258.5、172.8、215.3,城市18~45岁成年人尿碘水平低于农村(Z=-4.020,P=0.000),孕妇尿碘水平高于农村(Z=1.424,P=0.035),差异有统计学意义。与城市相比较,农村孕妇、哺乳期妇女FT₃水平偏高(t=-3.933,P=0.000;t=-2.259,P=0.026);18~45岁成年人FT₄水平偏低(t=3.539,P=0.001)。农村孕妇TGAb、TMAb阳性率分别为43.6%、56.4%,哺乳期妇女TGAb、TMAb阳性率分别为33.3%、35.6%,均高于相应的城市人群。城市和农村不同人群甲状腺功能紊乱主要以亚甲状腺功能减退为主,不同人群各类型甲状腺功能紊乱发生率比较均无统计学意义。结论甘肃省武威市城市、农村各人群碘营养均处于充足状态,其中儿童碘营养过剩。城市、农村成年人、孕妇和哺乳期妇女存在碘营养水平或甲状腺激素水平差异。

English Abstract:

Objective To understand the iodine nutrition and thyroid function of different population in urban and rural areas of Gansu province and provide evidence for iodine supplementation. Methods A cross-sectional survey was performed in urban and rural children,adults,pregnant women and breastfeeding women in Wuwei from April 2009 to January 2010. Urine and fasting blood samples were collected from the subjects. Urine iodine content was measured with arsenic cerium catalytic spectrophatometry. The thyroid-stimulating hormone(TSH),free thyroid hormone(FT₄) and three free triiodothyronine(FT₃) were detected by using direct chemiluminescence immunoassy. Non parametric test was used to compare the urinary iodine and TSH group. t test was used to compare FT₄,FT₃. χ² test was used to compare the rate. Results The medians of urinary iodine level(μg/L) were 358.6,189.0,255.4 and 239.5 in urban children,adults,pregnant women and breastfeeding women and 387.6,258.5,172.8 and 215.3 in rural children,adults,pregnant women and breastfeeding women respectively. The median of urinary iodine of urban adults was significantly lower than that in rural adults (Z=-4.020,P=0.000) and the medians of urinary iodine level of urban pregnant women was higher than that in rural pregnant women(Z=1.424,P=0.035). The mean value of FT₃ in rural pregnant women and breastfeeding women were higher than that in urban groups (t=-3.933,P=0.000;t=-2.259,P=0.026). The mean value of FT₄ in urban adults was higher than that in rural adults(t=3.539,P=0.001). The positive rate of TGAb and TMAb in rural pregnant women and breastfeeding women were 43.6%,56.4% and 33.3%,35.6%,respectively,which were higher than those in urban groups. Subclinical hypothyroidism in all thyroid function disorders was common in all the groups. No statistical significant difference in all thyroid function disorders were found in different population. Conclusion The iodine nutrition were in good status in both urban population and rural population,the children's iodine nutrition was surplus. Statistical differences existed in iodine nutrition status or thyroid hormone level between urban and rural adults,pregnant women and breastfeeding women.

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