| 刘佳,樊盼英,薛秀娟,孙国清,刘春华,田随安,李洁,李宁,孙定勇,朱谦,王哲.河南省2012－2014年新报告HIV感染者中HCV抗体流行状况分析[J].Chinese journal of Epidemiology,2015,36(11):1269-1273 |
| 河南省2012－2014年新报告HIV感染者中HCV抗体流行状况分析 |
| Prevalence of hepatitis C virus antibody among newly reported HIV infection cases in Henan, 2012-2014 |
| Received:March 19, 2015 |
| DOI：10.3760/cma.j.issn.0254-6450.2015.11.017 |
| KeyWord: 艾滋病病毒 丙型肝炎病毒抗体 新报告 |
| English Key Word: HIV Anti-HCV New report |
| FundProject:河南省医学科技攻关计划项目(201404045);河南省重点科技攻关计划项目(142102310076);国家科技重大专项(2012ZX10004905-001-003) |
| Author Name | Affiliation | E-mail | | Liu Jia | Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Fan Panying | Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Xue Xiujuan | Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Sun Guoqing | Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Liu Chunhua | Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Tian Suian | Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Li Jie | Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Li Ning | Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Sun Dingyong | Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Zhu Qian | Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Wang Zhe | Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | wangzhe@hncdc.com.cn |
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| Abstract: |
| 目的 了解河南省2012－2014年新报告HIV感染者中HCV抗体的流行情况。方法 通过艾滋病综合防治数据信息管理系统对河南省2012年7月1日至2014年6月30日新报告的HIV感染者进行信息整理、HIV-1 BED新发感染检测和HCV抗体检测。结果 4 267例新报告HIV感染者中HCV抗体阳性率为13.19%(563/4 267),感染途径为注射吸毒者的HCV抗体阳性率最高(77.27%),采血浆/输血、异性性传播、同性性传播和母婴传播人群的HCV抗体阳性率分别为15.06%、15.81%、3.74%和8.96%。开封(32.04%)、驻马店(25.00%)、商丘(25.00%)、周口(18.86%)和南阳(14.67%)为HCV抗体阳性率最高的前五个省辖市。BED阳性者(HIV新近感染者)中HCV抗体阳性率为7.50%(86/1 146)。多因素logistic回归分析发现:BED阴性、年龄>40岁、农民、HIV感染途径为注射吸毒以及报告地区为开封市、南阳市、商丘市、驻马店市和周口市为HCV感染的危险因素。结论 2012－2014年河南省新报告HIV感染者中HCV抗体流行率有降低的趋势,但是部分地区和重点人群仍存在较高的HCV抗体流行率。 |
| English Abstract: |
| Objective To study the prevalence of antibody to hepatitis C virus (anti-HCV) among newly reported HIV infection cases in Henan province,2012-2014. Methods HIV-1 BED incidence test and anti-HCV test were conducted in newly diagnosed HIV infection cases in Henan, which were reported through national AIDS information system between 1 July 2012 and 30 June 2014. Results The data of 4 267 newly reported HIV-1 infection cases were analyzed, the positive rate of anti-HCV was 13.19% (563/4 267). The anti HCV was highest in those infected with HIV through injection drug use (77.27%), the anti-HCV positive rates in those infected with HIV through blood donation/transfusion, heterosexual contact, homosexual contact and mother-to-child transmission were 15.06%, 15.81%, 3.74% and 8.96%, respectively. Kaifeng (32.04%), Nanyang (14.67%), Shangqiu (25.00%), Zhumadian (25.00%) and Zhoukou(18.86%) were the first five prefectures with the high anti-HCV positive rates. The anti-HCV positive rate in BED positive patients (recent HIV-1 infections) was 7.50% (86/1 146). The multivariate logistic regressions analysis revealed that BED negative, aged >40 years, being farmer, HIV infection though injection drug use and living in in Kaifeng, Nanyang, Shangqiu, Zhumadian and Zhoukou were the risk factors for HCV infection. Conclusion The positive rate of anti-HCV declined between 2012-2014 in newly reported HIV infection cases in Henan, but the positive rate of anti-HCV was high in risk population and in some areas. |
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