1990-2014年中国40岁及以上人群慢性阻塞性肺疾病患病率Meta分析

包鹤龄; 方利文; 王临虹

Abstract

包鹤龄,方利文,王临虹.1990-2014年中国40岁及以上人群慢性阻塞性肺疾病患病率Meta分析[J].Chinese journal of Epidemiology,2016,37(1):119-124

1990-2014年中国40岁及以上人群慢性阻塞性肺疾病患病率Meta分析

Prevalence of chronic obstructive pulmonary disease among community population aged ≥40 in China: a Meta-analysis on studies published between 1990 and 2014

Received:May 31, 2015

DOI：10.3760/cma.j.issn.0254-6450.2016.01.026

KeyWord: 慢性阻塞性肺疾病患病率 Meta分析

English Key Word: Chronic obstructive pulmonary diseases Prevalence Meta-analysis

FundProject:

Author Name	Affiliation	E-mail
Bao Heling	Institute for Chronic Respiratory Diseases Prevention and Control, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China
Fang Liwen	Institute for Chronic Respiratory Diseases Prevention and Control, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China	fanglw@chinawch.org.cn
Wang Linhong	Institute for Chronic Respiratory Diseases Prevention and Control, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China

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Abstract:

目的分析1990-2014年中国大陆地区≥40岁社区人群COPD患病率。方法系统检索中国生物医学文献数据库、中文期刊全文数据库、万方电子期刊、PubMed、EBSCO等文献数据库,纳入1990-2014年公开发表的有关中国大陆地区居民COPD患病率的研究文献。采用Stata 12.0软件和Mantel-Haenszel固定效应和随机效应模型对结果进行合并分析。结果共纳入30篇文献,中国≥40岁人群COPD患病率为9.9%(95%CI:8.8%～11.0%)。其中男性患病率为13.0%(95%CI:11.5%～14.4%),高于女性的5.8%(95%CI:4.9%～6.6%);COPD患病率随年龄增长而上升,由40～49岁的3.2%(95%CI:2.5%～3.9%)上升至≥70岁的20.3%(95%CI:18.2%～22.4%);不同区域、城乡人群间COPD患病率差异无统计学意义。结论我国近20年≥40岁人群COPD患病率呈现缓慢上升趋势;不同研究在COPD诊断方法、诊断标准、样本构成等存在差异,使研究结果间存在显著的异质性差异。

English Abstract:

Objective To understand the prevalence of chronic obstructive pulmonary disease (COPD) among the community population aged ≥40 years in China from 1990 to 2014. Methods The studies on the prevalence of COPD among the community population in China published from 1990 to 2014 were retrieved from the following databases: Chinese BioMedical Literature Database (CBM), Chinese Journal Full-text Database (CNKI), Wanfang Database, PubMed and EBSCO. Mantel-Haenszel fixed effect and random effect model and software Stata were used for statistical analysis. Results A total 30 studies were included in the Meta analysis. The pooled prevalence of COPD was 9.9%(95%CI: 8.8%-11.0%). The prevalence was higher in males (13.0%, 95%CI: 11.5%-14.4%) than in females (5.8%, 95%CI: 4.9%-6.6%), and the prevalence of COPD increased with age obviously from 3.2% in age group 40-49 years (95%CI: 2.5%-3.9%) to 20.3% in age group ≥70 years (95%CI: 18.2%-22.4%). The differences in prevalence among different areas had no statistical significance. Conclusions The prevalence of COPD in population aged ≥40 years increased gradually in China in recent 20 years. Obvious heterogeneity was found among the results of the studies due to the different diagnostic standards and sample sizes.

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