| 周龙,赵连成,李莹,郭敏,武阳丰.成年早期体重状态及至中年期体重变化与新发2型糖尿病的关系[J].Chinese journal of Epidemiology,2016,37(3):339-343 |
| 成年早期体重状态及至中年期体重变化与新发2型糖尿病的关系 |
| Relationship between body weight status in early adulthood and body weight change at middle age in adults and type 2 diabetes mellitus |
| Received:August 22, 2015 |
| DOI：10.3760/cma.j.issn.0254-6450.2016.03.009 |
| KeyWord: 体重 肥胖 糖尿病,2型 |
| English Key Word: Body weight Obesity Type 2 diabetes mellitus |
| FundProject:国家"九五"科技攻关计划(96-906-02-01) |
| Author Name | Affiliation | E-mail | | Zhou Long | National Center for Cardiovascular Diseases and Department of Community Prevention and Treatment of Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China | | | Zhao Liancheng | National Center for Cardiovascular Diseases and Department of Community Prevention and Treatment of Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China | zhaolch@163.com | | Li Ying | National Center for Cardiovascular Diseases and Department of Community Prevention and Treatment of Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China | | | Guo Min | National Center for Cardiovascular Diseases and Department of Community Prevention and Treatment of Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China | | | Wu Yangfeng | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | |
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| Abstract: |
| 目的 探讨成年早期体重状态及至中年期体重变化与2型糖尿病间的关系。方法 利用中国心血管流行病学多中心协作研究的14组35~59岁(男女各半)人群样本心血管病危险因素调查资料,采用多因素logistic回归分别探讨25岁时体重状态和随后其变化与新发糖尿病的关系。结果 共12 674人纳入分析,其25岁时低体重组(BMI<18.5 kg/m2)、正常体重组(BMI 18.5~23.9 kg/m2)、超重组(BMI 24.0~27.9 kg/m2)和肥胖组(BMI≥28.0 kg/m2)中年期糖尿病发病率分别为2.4%(30/1 263)、2.8%(266/9 562)、4.0%(70/1 739)和6.4%(7/110),呈明显上升趋势(趋势检验P<0.01)。25岁至中年时期体重变化<-7.5 kg组、-7.5~-2.6 kg组、-2.5~2.5 kg组、2.6~7.5 kg组、7.6~12.5 kg组和>12.5 kg组糖尿病发病率分别为2.5%(18/712)、1.3%(21/1 629)、2.1%(48/2 330)、2.3%(59/2 585)、3.7%(94/2 518)和4.6%(133/2 900),也呈明显上升趋势(趋势检验P<0.01)。多因素logistic回归分析显示,25岁时超重/肥胖以及随后的体重增加均与中年时期新发糖尿病正相关(趋势检验P<0.01)。结论 成年早期超重/肥胖以及随后的体重增加均与中年期新发糖尿病独立相关。 |
| English Abstract: |
| Objective To explore the relationship between weight status in early adulthood and body weight change at middle age in adults and type 2 diabetes mellitus (T2DM). Methods The data of 14 population samples from China Multicenter Collaborative Study of Cardiovascular Epidemiology conducted in 1998 were used. Approximately 1 000 men and women in each sample were surveyed for cardiovascular disease risk factors, including body weight at age 25 years. The body mass index (BMI) at the age 25 years was calculated. The association between body weight in early adulthood and body weight change at middle age and T2DM was examined by using logistic regression model. Results The incidence of T2DM in low weight group (BMI<18.5 kg/m2), normal weight group (BMI: 18.5-23.9 kg/m2), overweight group (BMI: 24.0-27.9 kg/m2) and obese group (BMI:≥28.0 kg/m2) at 25 years old were 2.4%(30/1 263), 2.8%(266/9 562), 4.0%(70/1 739) and 6.4%(7/110), respectively (P value for trend<0.01). The incidence of T2DM for adults with weight change <-7.5 kg, -7.5- -2.6 kg, -2.5-2.5 kg, 2.6-7.5 kg, 7.6-12.5 kg and >12.5 kg at middle age were 2.5% (18/712), 1.3%(21/1 629), 2.1%(48/2 330), 2.3%(59/2 585), 3.7%(94/2 518), and 4.6%(133/2 900) respectively. (P value for trend <0.01), Multivariate logistic regression analysis showed that overweight and obesity at age 25 years and subsequent weight gain were positively correlated with T2DM after adjusted other risk factors (all P values for trend <0.01). Conclusion Overweight and obesity in early adulthood and weight gain at middle age were both independently associated with the increased risk of T2DM in middle-aged men and women. |
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