天津市浴池男男性行为人群HIV新发感染队列研究

于茂河; 江国虹; 斗智; 李志军; 郭燕; 徐鹏; 杨杰; 徐杰

Abstract

于茂河,江国虹,斗智,李志军,郭燕,徐鹏,杨杰,徐杰.天津市浴池男男性行为人群HIV新发感染队列研究[J].Chinese journal of Epidemiology,2016,37(3):362-366

天津市浴池男男性行为人群HIV新发感染队列研究

HIV infection incidence among men who have sex with men in common bathing pool in Tianjin: a cohort study

Received:September 30, 2015

DOI：10.3760/cma.j.issn.0254-6450.2016.03.014

KeyWord: 同性恋浴池男男性行为人群 HIV新发感染队列

English Key Word: Homosexual common bathing pool Men who have sex with men HIV infection Cohort

FundProject:中美艾滋病防治合作项目-天津同志浴池男男性行为者艾滋病预防综合干预试点;天津市卫生局科技基金项目(2013KZ052);天津市卫生行业重点攻关项目(12KG129)

Author Name	Affiliation	E-mail
Yu Maohe	Tianjin Center for Disease Control and Prevention, Tianjin 300011, China
Jiang Guohong	Tianjin Center for Disease Control and Prevention, Tianjin 300011, China
Dou Zhi	National Center for STD/AIDS Control and Prevention, Chinese Center for Disease Control and Prevention Beijing 102206, China
Li Zhijun	United States Center of Disease Control Global AIDS Program, China Office, Beijing 100600, China
Guo Yan	Tianjin Center for Disease Control and Prevention, Tianjin 300011, China
Xu Peng	Tianjin Center for Disease Control and Prevention, Tianjin 300011, China
Yang Jie	Shenlan Public Health Counsel Service Center, Tianjin 300121, China
Xu Jie	National Center for STD/AIDS Control and Prevention, Chinese Center for Disease Control and Prevention Beijing 102206, China	xujie@chinaaids.cn

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Abstract:

目的通过队列研究分析天津市浴池MSM人群HIV新发感染状况及影响因素,为在MSM人群中开展HIV感染的预防和干预提供依据。方法以经常光顾天津市某同性恋浴池、曾发生过男男性行为的MSM为研究对象,于2011年4月至2013年9月采用同伴推动法招募研究对象,建立MSM人群开放性队列,完成HIV检测和基线调查,并进行跟踪随访检测。调查内容包括人口学特征、艾滋病相关知识知晓情况、艾滋病相关行为情况等信息。以随访过程中"HIV阳转"为结局因变量,同时,将从研究对象进入队列到出现HIV阳转的时间为时间因变量,应用Cox比例风险模型进行浴池型MSM人群HIV新发感染影响因素的分析。结果调查期间符合条件的研究对象733例,共新发HIV感染59例,队列随访累积观察时间为7 384.9人月,HIV新发感染率为9.59/100人年(95%CI:7.3/100人年~11.92/100人年)。多因素 Cox 回归分析显示,天津市浴池型MSM人群的危险因素包括:年龄较低者相比较年长者艾滋病知识知晓率低者(HR=1.82,95%CI:1.03~2.66)相比较知晓率高者,多性伴者(HR=1.74,95%CI:1.26~2.58)相比较固定性伴者,正在感染梅毒者(HR=2.36,95%CI:1.31~3.27),均易发生HIV的新发感染。结论同性恋浴池MSM人群中年龄较低、艾滋病知识知晓率低、多性伴、梅毒感染为该人群HIV新发感染的危险因素,应针对危险因素加强浴池型MSM人群HIV新发感染的监测和干预。

English Abstract:

Objective To investigate incidence of HIV infection and identify associated risk factors among men who have sex with men (MSM) in common bathing pools in Tianjin. Methods A prospective cohort study was conducted among the MSM recruited in a common bathing pool in Tianjin from 2011 to 2013. A total of 733 MSM were surveyed to obtain the information about their sociodemographic characteristics, HIV-related knowledge awareness and sexual behaviors, and subsequent follow-up surveys were carried out every four months. Cox regression analysis was conducted to identify the risk factors for HIV infection. Results A total of 59 HIV infection cases were found in the 2.5-years follow-up survey. The cumulative follow-up time was 7 384.9 person- months. The incidence rate of HIV infection was 9.59/100 person-year. The multivariate Cox regression analysis showed that young age, low score of HIV/AIDS knowledge awareness (HR=1.82, 95%CI:1.03-2.66), having two and more sexual partners during past 6 months (HR=1.74, 95%CI: 1.26-2.58) and syphilis (HR=2.36, 95%CI:1.31-3.27) were significantly associated with HIV infection in this MSM cohort. Conclusions Low score of HIV/AIDS knowledge awareness, young age, having two and more sexual partners during past 6 months and syphilis were the risk factors for HIV infection in MSM in common bathing pools. It is necessary to strengthen the HIV surveillance and intervention in this population.

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