| 杨文杰,樊盼英,梁妍,聂玉刚,朱谦,李宁,孙定勇,王哲.河南省2002-2014年艾滋病患者不同时期开始抗病毒治疗生存效果分析[J].Chinese journal of Epidemiology,2016,37(6):826-830 |
| 河南省2002-2014年艾滋病患者不同时期开始抗病毒治疗生存效果分析 |
| Survival effect after antiretroviral treatment initiating at different times on AIDS patients in Henan province, 2002-2014 |
| Received:October 12, 2015 |
| DOI：10.3760/cma.j.issn.0254-6450.2016.06.017 |
| KeyWord: 艾滋病 抗病毒治疗 生存分析 影响因素 |
| English Key Word: AIDS Initiation of antiretroviral treatment Survival analysis Effect factor |
| FundProject:国家科技重大专项(2012ZX10004905);河南省创新型科技人才队伍建设工程 |
| Author Name | Affiliation | E-mail | | Yang Wenjie | STD/AIDS Prevention and Control Institute, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Fan Panying | STD/AIDS Prevention and Control Institute, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Liang Yan | STD/AIDS Prevention and Control Institute, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Nie Yugang | STD/AIDS Prevention and Control Institute, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Zhu Qian | STD/AIDS Prevention and Control Institute, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Li Ning | STD/AIDS Prevention and Control Institute, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Sun Dingyong | STD/AIDS Prevention and Control Institute, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | | | Wang Zhe | STD/AIDS Prevention and Control Institute, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China | wangzhe@hncdc.com.cn |
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| Abstract: |
| 目的 了解不同时期开始抗病毒治疗对艾滋病患者生存状况的影响,并分析其影响因素。方法 利用国家艾滋病抗病毒治疗信息系统,收集河南省2002-2014年加入抗病毒治疗的艾滋病患者基本和随访信息,并按照基线免疫学水平,将所有研究对象分为早期治疗组[基线CD4+T淋巴细胞计数(CD4)在350~500个/μl]和常规治疗组(基线CD4≤350个/μl),采用生存分析的方法进行回顾研究。结果 共纳入37169例艾滋病患者,其中常规治疗组32129例,早期治疗组5040例,常规治疗组和早期治疗组的病死率分别为4.3/100人年和1.8/100人年,治疗11年累积生存率分别为67.9%和82.3%。多因素调整后分析发现,患者性别、年龄、婚姻状况、感染途径、基线症状数、近7 d是否漏服药物和教育程度为常规治疗组生存时间的影响因素(P<0.05)。患者性别、年龄、婚姻状况和近7 d是否漏服药物为早期治疗组生存时间的影响因素(P<0.05)。结论 对符合治疗条件的艾滋病患者尽早开展抗病毒治疗,加大对艾滋病患者服药依从性的教育及随访管理力度,可以延长艾滋病患者抗病毒治疗后的生存时间。 |
| English Abstract: |
| Objective To study the survival effect of AIDS patients after the antiretroviral treatment that initiated at different times and to understand the factors associated with the survival time. Methods Information on AIDS patients who started receiving the antiretroviral therapy during 2002-2014 was collected from the Chinese HIV/AIDS Integrated Control System in Henan province.According to the level of baseline immunology, all the participants were divided into earlier treatment group[Baseline CD4+T lymphocyte cell counts (CD4) between 350/μl and 500/μl] or conventional treatment group (Baseline CD4 cell counts ≤ 350/μl). Data was analyzed with both Survival and Review methods. Results A total number of 37 169 cases were selected, including 32 129 cases in the conventional treatment group and 5 040 cases in the earlier treatment group. Mortalities in the conventional treatment group and earlier treatment group were 4.3/100 person year and 1.8/100 person year, respectively. Data on the 11-year cumulative survival rate of both the conventional treatment group and earlier treatment group were 67.9% and 82.3%, respectively. By means of multi-variable analysis, we found that factors as gender, age, marital status, route of infection, number of symptoms, missed taking drugs in the past 7 days, degree of education at baseline of conventional treatment group etc. were associated with survival time of patients after the initiation of antiretroviral treatment (ART) (P<0.05) while factors as gender, age, marital status, ever missed taking drugs in the past 7 days at baseline etc. in the earlier treatment group were associated with the survival time of patients after the ART initiation (P<0.05). Conclusion Strategy including earlier initiation of antiretroviral treatment on AIDS patients who had met the treatment criteria and programs related to the improvement on adherence to medication, could prolong the survival time of AIDS patients, in Henan province. |
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