| 王小红,钱艺美,缪铃,乐瑶,杜娟.高危型HPV E6/E7 mRNA与宫颈癌相关性分析[J].Chinese journal of Epidemiology,2016,37(7):1003-1005 |
| 高危型HPV E6/E7 mRNA与宫颈癌相关性分析 |
| Correlation between high risk type human papillomavirus E6/E7 mRNA and cervical cancer |
| Received:January 25, 2016 |
| DOI：10.3760/cma.j.issn.0254-6450.2016.07.019 |
| KeyWord: 人乳头瘤病毒 宫颈癌 相关性 |
| English Key Word: Human papillomavirus Cervical cancer Correlation |
| FundProject:南京军区面上项目（14MS012）；解放军第一〇一医院院级科研课题（15YG11） |
| Author Name | Affiliation | E-mail | | Wang Xiaohong | Department of Obstetrics and Gynecology, 101 Hospital of Chinese People's Liberation Army, Wuxi 214044, China | xiaohong_wang101@163.com | | Qian Yimei | Department of Obstetrics and Gynecology, 101 Hospital of Chinese People's Liberation Army, Wuxi 214044, China | | | Miao Ling | Department of Obstetrics and Gynecology, 101 Hospital of Chinese People's Liberation Army, Wuxi 214044, China | | | Le Yao | Department of Obstetrics and Gynecology, 101 Hospital of Chinese People's Liberation Army, Wuxi 214044, China | | | Du Juan | Department of Obstetrics and Gynecology, 101 Hospital of Chinese People's Liberation Army, Wuxi 214044, China | |
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| Abstract: |
| 目的 探讨高危型HPV E6/E7 mRNA检出率与宫颈癌的相关性，为临床防治宫颈癌提供依据。方法 选择2015年收治的100例宫颈癌患者为A组，同期100例健康体检者为B组，采用荧光定量PCR检测入组患者高危型HPV E6/E7 mRNA和病理学检查，比较两组患者HPV E6/E7感染率和荧光定量PCR检查效率，分析HPV E6/E7感染与宫颈鳞状上皮病变的相关性。结果 A组阳性76例，阳性率为76.0%；B组阳性13例，阳性率为13.0%；A组阳性率高于B组，差异有统计学意义（χ2=24.522，P<0.001）。两组阳性预测值和阴性预测值比较，差异无统计学意义（P>0.05）。宫颈癌患者HPV E6/E7 mRNA阳性率（76.0%）高于高度宫颈鳞状上皮病变者（26.1%）、低度宫颈鳞状上皮病变者（17.6%）和非典型鳞状上皮细胞者（6.7%），差异有统计学意义（χ2=7.615，P=0.001； χ2=9.114，P=0.001； χ2=18.241，P<0.001）。结论 宫颈癌患者HPV E6/E7mRNA检出率高，且随宫颈鳞状上皮病变加重，其HPV E6/E7 mRNA阳性率越高。 |
| English Abstract: |
| Objective To investigate the correlation between the positive rate of high risk human papillomavirus (HPV) mRNA E6/E7 and cervical cancer, and provide evidence for the prevention and treatment of cervical cancer. Methods A total of 100 cervical cancer cases and 100 healthy controls were selected in our hospital from January 2015 to December 2015. The fluorescence quantitative PCR and pathological examination on HPV E6/E7 mRNA were carried out. The correlation between HPV E6/E7 mRNA and cervical squamous epithelial lesions were analyzed. Results In case group, the positive rate of HPV E6/E7 mRNA was 76.0% (76/100). In control group, the positive rate was 13.0% (13/100). The positive rate in case group was significantly higher than that in control group, and the difference was statistically significant (χ2=24.522, P<0.001). The positive predictive value and negative predictive value of the two groups were compared, and the difference was not significant (P>0.05). The positive rate of HPV E6/E7 mRNA was significantly higher than high-grade squamous intraepithelial lesion (SIL) rate (26.1%), low-grade SIL rate (17.6%) and atypical squamous cell hyperplasia rate (6.7%), the difference was statistically significant (χ2=7.615, P=0.001; χ2=9.114, P=0.001; χ2=18.241, P<0.001). Conclusions The detection rate of HPV E6/E7 mRNA in cervical cancer patients was high. And with the increased severity of cervical squamous epithelial lesions, the positive rate of HPV E6/E7 mRNA increased. |
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