| 刘红,高晓艳,付士红,李铭华,翟友刚,孟维珊,孙肖红,王环宇,吕志,申辛欣,曹玉玺,何英,梁国栋.基于第12节段基因序列的版纳病毒分子遗传进化分析[J].Chinese journal of Epidemiology,2016,37(9):1277-1282 |
| 基于第12节段基因序列的版纳病毒分子遗传进化分析 |
| Analysis on molecular genetic evolution of Banna virus based on the 12th segment |
| Received:March 07, 2016 |
| DOI：10.3760/cma.j.issn.0254-6450.2016.09.019 |
| KeyWord: 版纳病毒 虫媒病毒 系统进化分析 |
| English Key Word: Banna virus Arbovirus Phylogenetic analysis |
| FundProject:国家自然科学基金重大项目（81290342）；国家自然科学基金（81301479，81501757）；山东省自然科学基金（ZR2013HQ008）；传染病预防和控制重点实验室发展项目（2014SKLID103） |
| Author Name | Affiliation | E-mail | | Liu Hong | School of Life Sciences, Shandong University of Technology, Zibo 255000, China
Department of Virual Encephalitis, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | Gao Xiaoyan | Department of Virual Encephalitis, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | Fu Shihong | Department of Virual Encephalitis, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | Li Minghua | Department of Virual Encephalitis, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | Zhai Yougang | Department of Virual Encephalitis, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | Meng Weishan | Department of Virual Encephalitis, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | Sun Xiaohong | Department of Virual Encephalitis, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | Wang Huanyu | Department of Virual Encephalitis, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | Lyu Zhi | Department of Virual Encephalitis, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | Shen Xinxin | Department of Virual Encephalitis, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | Cao Yuxi | Department of Virual Encephalitis, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | He Ying | Department of Virual Encephalitis, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | Liang Guodong | Department of Virual Encephalitis, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | gdliang@hotmail.com |
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| Abstract: |
| 目的 了解自1980-2012年在世界各地分离的版纳病毒分子遗传进化特征。方法 采用多种生物信息学分析方法，对1980-2012年我国及世界各地分离的版纳病毒进行基于第12节段基因序列的系统进化、分子溯源分析。结果 版纳病毒的共同进化祖先出现时间为315（95% HPD：63～619）年前，第12节段的进化速率为2.33×10-3（95% HPD：2.84×10-4～8.52×10-3）碱基替换/位点/年，提示版纳病毒属于新发快速进化的虫媒病毒。结论 版纳病毒属于快速进化的新发虫媒病毒，其地域分布范围进一步扩大且已经分化出新的病毒变种，应加强对该病毒在自然界分布及其致病性的监测。 |
| English Abstract: |
| Objective To understand the evolution characteristics of Banna viruses (BAVs) isolated worldwide from 1980 to 2012. Methods In this study, a phylogenetic analysis using Bayesian Markov Chain Monte Carlo simulations was conducted on all available 12th segment of genes of BAVs isolated worldwide from 1980 to 2012 to investigate the evolutionary and epidemiologic dynamics of BAVs. Results The Bayesian phylogenetic analysis of BAVs revealed that the common ancestor of BAVs appeared 315 (95%HPD:63-619) years ago. The evolutionary rate of BAV based on the 12th segment gene was estimated to be 2.33×10-3 (95%HPD:2.84×10-4-8.52×10-3) substitution per site per year, indicating BAV belong to an emerging arbovirus with rapid evolution. Conclusion The evolution of emerging BAVs is rapid and the distribution of BAVs has expanded with new variant being detected, so it is necessary to enhance the surveillance to fully understand the natural distribution and pathogenicity of BAVs. |
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